留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

烧伤后侵袭性真菌感染的研究进展

蔡悦 程兴 詹剑华 罗锦花 廖文强

蔡悦, 程兴, 詹剑华, 等. 烧伤后侵袭性真菌感染的研究进展[J]. 中华烧伤与创面修复杂志, 2023, 39(3): 269-274. DOI: 10.3760/cma.j.cn501225-20220523-00199.
引用本文: 蔡悦, 程兴, 詹剑华, 等. 烧伤后侵袭性真菌感染的研究进展[J]. 中华烧伤与创面修复杂志, 2023, 39(3): 269-274. DOI: 10.3760/cma.j.cn501225-20220523-00199.
Cai Y,Cheng X,Zhan JH,et al.Research advances on invasive fungal infections after burns[J].Chin J Burns Wounds,2023,39(3):269-274.DOI: 10.3760/cma.j.cn501225-20220523-00199.
Citation: Cai Y,Cheng X,Zhan JH,et al.Research advances on invasive fungal infections after burns[J].Chin J Burns Wounds,2023,39(3):269-274.DOI: 10.3760/cma.j.cn501225-20220523-00199.

烧伤后侵袭性真菌感染的研究进展

doi: 10.3760/cma.j.cn501225-20220523-00199
基金项目: 

江西省科技计划项目 20171BBG70061, 20202BBG73020

详细信息
    通讯作者:

    詹剑华,Email:zjhseasky@163.com

Research advances on invasive fungal infections after burns

Funds: 

Science and Technology Plan Project of Jiangxi Province of China 20171BBG70061, 20202BBG73020

More Information
  • 摘要: 侵袭性真菌感染(IFI)是烧伤患者严重的并发症之一。近年来广谱抗生素的逐步研发应用致使菌群严重失调,而抗真菌药物的广泛预防性使用则导致耐药真菌日渐增加。IFI临床治疗难度大,预后差,IFI所致烧伤患者的病死率逐年上升。该文从烧伤后IFI的流行病学特点、相关危险因素、诊断方法及治疗进展方面进行综述,旨在为烧伤后IFI的预防和治疗提供新的思路及依据。

     

  • [1] 《中华烧伤杂志》编辑委员会.烧伤侵袭性真菌感染诊断与防治指南(2012版)[J].中华烧伤杂志,2012,28(2):81-86.DOI: 10.3760/cma.j.issn.1009-2587.2012.02.001.
    [2] LuoG,TanJ,PengY,et al.Guideline for diagnosis, prophylaxis and treatment of invasive fungal infection post burn injury in China 2013[J/OL].Burns Trauma,2014,2(2):45-52[2022-05-23].https://pubmed.ncbi.nlm.nih.gov/27602362/.DOI: 10.4103/2321-3868.130182.
    [3] PalackicA,PoppD,TapkingC,et al.Fungal infections in burn patients[J].Surg Infect (Larchmt),2021,22(1):83-87.DOI: 10.1089/sur.2020.299.
    [4] SoboutiB,DahmardeheiM,FallahS,et al.Candidemia in pediatric burn patients: risk factors and outcomes in a retrospective cohort study[J].Curr Med Mycol,2020,6(3):33-41.DOI: 10.18502/cmm.6.3.4663.
    [5] RafikA,DiouriM,BahecharN,et al.Epidemiology of nosocomial fungal infections in the National Center for Burns in Casablanca, Morocco[J].Ann Burns Fire Disasters,2016,29(2):90-93.
    [6] Badino VarelaMG,SnitmanGV,LandaburuMF,et al.Fungal identification in burn patients. A retrospective study and risk factors[J].Medicina (B Aires),2021,81(5):780-785.
    [7] ZhouJ,TanJ,GongY,et al.Candidemia in major burn patients and its possible risk factors: a 6-year period retrospective study at a burn ICU[J].Burns,2019,45(5):1164-1171.DOI: 10.1016/j.burns.2019.01.005.
    [8] 张成,龚雅利,罗小强,等.重度烧伤患者真菌血流感染的病原学特征分析[J].中华烧伤杂志,2020,36(1):37-41.DOI: 10.3760/cma.j.issn.1009-2587.2020.01.007.
    [9] VaeziA,FakhimH,KhodavaisyS,et al.Epidemiological and mycological characteristics of candidemia in Iran: a systematic review and meta-analysis[J].J Mycol Med,2017,27(2):146-152.DOI: 10.1016/j.mycmed.2017.02.007.
    [10] TadecL,TalarminJP,GastinneT,et al.Epidemiology, risk factor, species distribution, antifungal resistance and outcome of candidemia at a single French hospital: a 7-year study[J].Mycoses,2016,59(5):296-303.DOI: 10.1111/myc.12470.
    [11] RodriguezL,BustamanteB,HuarotoL,et al.A multi-centric study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes[J].PLoS One,2017,12(4):e0175172.DOI: 10.1371/journal.pone.0175172.
    [12] Van BangBN,Thanh XuanN,XuanQuang D,et al.Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam[J].Curr Med Mycol,2020,6(3):42-49.DOI: 10.18502/cmm.6.3.4664.
    [13] DevauchelleP,JeanneM,FréalleE.Mucormycosis in burn patients[J].J Fungi (Basel),2019,5(1):25.DOI: 10.3390/jof5010025.
    [14] MontazeriA,ZandiH,TeymouriF,et al.Microbiological analysis of bacterial and fungal bioaerosols from burn hospital of Yazd (Iran) in 2019[J].J Environ Health Sci Eng,2020,18(2):1121-1130.DOI: 10.1007/s40201-020-00531-7.
    [15] MaurelV,DenisB,CambyM,et al.Outcome and characteristics of invasive fungal infections in critically ill burn patients: a multicenter retrospective study[J].Mycoses,2020,63(6):535-542.DOI: 10.1111/myc.13068.
    [16] MitchellTA,HardinMO,MurrayCK,et al.Mucormycosis attributed mortality: a seven-year review of surgical and medical management[J].Burns,2014,40(8):1689-1695.DOI: 10.1016/j.burns.2014.03.013.
    [17] HortaR,TomazD,EgiptoP,et al.The outcome of fungal infections in a burn intensive care unit: a study of 172 patients[J].Ann Burns Fire Disasters,2020,33(2):101-106.
    [18] 金少华,李传吉,张龙,等.成批烧伤患者感染病原菌情况及耐药性分析[J].中华烧伤杂志,2015,31(4):300-303.DOI: 10.3760/cma.j.issn.1009-2587.2015.04.018.
    [19] LinYL,ChenIC,YenJH,et al.Invasive candidiasis in hospitalized patients with major burns[J].J Pers Med,2022,12(1):47.DOI: 10.3390/jpm12010047.
    [20] WhaleySG,BerkowEL,RybakJM,et al.Azole antifungal resistance in Candida albicans and emerging non-albicans Candida species[J].Front Microbiol,2017,7:2173.DOI: 10.3389/fmicb.2016.02173.
    [21] El-Ganiny AM,Yossef NE,Kamel HA.Prevalence and antifungal drug resistance of nosocomial Candida species isolated from two university hospitals in Egypt[J].Curr Med Mycol,2021,7(1):31-37.DOI: 10.18502/cmm.7.1.6181.
    [22] TortoranoAM,PrigitanoA,MorroniG,et al.Candidemia: evolution of drug resistance and novel therapeutic approaches[J].Infect Drug Resist,2021,14:5543-5553.DOI: 10.2147/IDR.S274872.
    [23] KhairatSM,SayedAM,NabihM,et al.Prevalence of Candida blood stream infections among children in tertiary care hospital: detection of species and antifungal susceptibility[J].Infect Drug Resist,2019,12:2409-2416.DOI: 10.2147/IDR.S196972.
    [24] 刘正印,王贵强,朱利平,等.隐球菌性脑膜炎诊治专家共识[J].中华内科杂志,2018,57(5):317-323.DOI: 10.3760/cma.j.issn.0578-1426.2018.05.003.
    [25] McCartyTP,LuethyPM,BaddleyJW,et al.Clinical utility of antifungal susceptibility testing[J].JAC Antimicrob Resist,2022,4(3):dlac067.DOI: 10.1093/jacamr/dlac067.
    [26] CornelyOA,Alastruey-IzquierdoA,ArenzD,et al.Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium[J].Lancet Infect Dis,2019,19(12):e405-e421.DOI: 10.1016/S1473-3099(19)30312-3.
    [27] StruckMF,GilleJ.Fungal infections in burns: a comprehensive review[J].Ann Burns Fire Disasters,2013,26(3):147-153.
    [28] OkunoE,JarrosIC,Bonfim-MendonçaPS,et al.Candida parapsilosis isolates from burn wounds can penetrate an acellular dermal matrix[J].Microb Pathog,2018,118:330-335.DOI: 10.1016/j.micpath.2018.03.058.
    [29] WhiteLP,PriceJS.Recent advances and novel approaches in laboratory-based diagnostic mycology[J].J Fungi (Basel),2021,7(1):41.DOI: 10.3390/jof7010041.
    [30] Freeman WeissZ,LeonA,KooS.The evolving landscape of fungal diagnostics, current and emerging microbiological approaches[J].J Fungi (Basel),2021,7(2):127.DOI: 10.3390/jof7020127.
    [31] VatanshenassanM,BoekhoutT,Lass-FlörlC,et al.Proof of concept for MBT ASTRA, a rapid matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS)-based method to detect caspofungin resistance in Candida albicans and Candida glabrata[J].J Clin Microbiol,2018,56(9):e00420-18.DOI: 10.1128/JCM.00420-18.
    [32] MondayLM,Parraga AcostaT,AlangadenG.T2Candida for the diagnosis and management of invasive Candida infections[J].J Fungi (Basel),2021,7(3):178.DOI: 10.3390/jof7030178.
    [33] OliveiraLVN,WangR,SpechtCA,et al.Vaccines for human fungal diseases: close but still a long way to go[J].NPJ Vaccines,2021,6(1):33.DOI: 10.1038/s41541-021-00294-8.
    [34] 张婷婷,孙玲洁,冯四洲.艾沙康唑治疗侵袭性真菌病的临床研究进展[J].中国感染与化疗杂志,2022,22(3):360-365.DOI: 10.16718/j.1009-7708.2022.03.023.
    [35] HoeniglM,SpruteR,EggerM,et al.The antifungal pipeline: fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin[J].Drugs,2021,81(15):1703-1729.DOI: 10.1007/s40265-021-01611-0.
    [36] ThompsonGR,SorianoA,SkoutelisA,et al.Rezafungin versus caspofungin in a phase 2, randomized, double-blind study for the treatment of candidemia and invasive candidiasis: the STRIVE trial[J].Clin Infect Dis,2021,73(11):e3647-e3655.DOI: 10.1093/cid/ciaa1380.
    [37] ShawKJ,IbrahimAS.Fosmanogepix: a review of the first-in-class broad spectrum agent for the treatment of invasive fungal infections[J].J Fungi (Basel),2020,6(4):239.DOI: 10.3390/jof6040239.
    [38] GhannoumM,LongL,LarkinEL,et al.Evaluation of the antifungal activity of the novel oral glucan synthase inhibitor SCY-078, singly and in combination, for the treatment of invasive aspergillosis[J].Antimicrob Agents Chemother,2018,62(6):e00244-18.DOI: 10.1128/AAC.00244-18.
    [39] ZhangJ,LiuH,XiL,et al.Antifungal susceptibility profiles of olorofim (formerly F901318) and currently available systemic antifungals against mold and yeast phases of Talaromyces marneffei[J].Antimicrob Agents Chemother,2021,65(6):e00256-21.DOI: 10.1128/AAC.00256-21.
    [40] NaritaK,AsanoK,NaitoK,et al.222-nm UVC inactivates a wide spectrum of microbial pathogens[J].J Hosp Infect,2020,105(3):459-467.DOI: 10.1016/j.jhin.2020.03.030.
    [41] ZhangY,ZhuY,ChenJ,et al.Antimicrobial blue light inactivation of Candida albicans: in vitro and in vivo studies[J].Virulence,2016,7(5):536-545.DOI: 10.1080/21505594.2016.1155015.
    [42] 庞家胤,和亚雄,郑梦雪,等.光动力抗菌疗法对多重耐药铜绿假单胞菌体外杀伤作用的研究[J].第三军医大学学报,2021,43(7):599-605.DOI: 10.16016/j.1000-5404.202012135.
    [43] TanakaJL,Costa-OrlandiCB,BurdBS,et al.Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp[J].Int J Biol Macromol,2021,189:597-606.DOI: 10.1016/j.ijbiomac.2021.08.102.
    [44] NiziołM,PalecznyJ,JunkaA,et al.3D printing of thermoresponsive hydrogel laden with an antimicrobial agent towards wound healing applications[J].Bioengineering (Basel),2021,8(6):79.DOI: 10.3390/bioengineering8060079.
    [45] KatzT,WasiakJ,ClelandH,et al.Incidence of non-candidal fungal infections in severe burn injury: an Australian perspective[J].Burns,2014,40(5):881-886.DOI: 10.1016/j.burns.2013.11.025.
  • 加载中
计量
  • 文章访问数:  219
  • HTML全文浏览量:  53
  • PDF下载量:  49
  • 被引次数: 0
出版历程
  • 收稿日期:  2022-05-23

目录

    /

    返回文章
    返回