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Volume 38 Issue 5
May  2022
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2022  >  38(5): 496-500
Wang MY,Cui P,Xin HM.Research advances of the roles of sphingosine-1-phosphate in acute lung injury[J].Chin J Burns Wounds,2022,38(5):496-500.DOI: 10.3760/cma.j.cn501120-20210703-00234.
Citation: Wang MY,Cui P,Xin HM.Research advances of the roles of sphingosine-1-phosphate in acute lung injury[J].Chin J Burns Wounds,2022,38(5):496-500.DOI: 10.3760/cma.j.cn501120-20210703-00234.
shu

Research advances of the roles of sphingosine-1-phosphate in acute lung injury

doi: 10.3760/cma.j.cn501120-20210703-00234
  • 1.

    College of Life Sciences, Guangxi Normal University, Guilin 541002, China

  • 2.

    Lung Injury Group of Guangxi Key Laboratory of Metabolic Diseases, Department of Burns and Plastic Surgery, the 924th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Guilin 541002, China

Funds:

Guangxi Science and Technology Base and Talent Special Program AD18126016

Science and Technology Planning Program of Guilin 20170109-35

Science and Technology Program of the 924th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army GS2020CZ06, GS2020FH08

More Information
  • Corresponding author: Xin Haiming, Email: xinhm123@163.com
  • Received Date: 2021-07-03
    Abstract
  • Sphingosine-1-phosphate (S1P) is the main metabolite produced in the process of phospholipid metabolism, which can promote proliferation, migration, and apoptosis of cells, and maintain the barrier function of vascular endothelium. The latest researches showed that S1P can alleviate acute lung injury (ALI) and the inflammation caused by ALI, while the dosage of S1P is still needed to be considered. Mesenchymal stem cells (MSCs) have been a emerging therapy with potential therapeutic effects on ALI because of their characteristics of self-replication and multi-directional differentiation, and their advantages in hematopoiesis, immune regulation, and tissue repair. S1P can promote differentiation of MSCs and participate in immune regulation, while MSCs can regulate the homeostasis of S1P in the body. The synergistic effect of S1P and MSC provides a new treatment method for ALI. This article reviews the production and biological function of S1P, receptor and signal pathway of S1P, the therapeutic effects of S1P on ALI, and the research advances of S1P combined with MSCs in the treatment of ALI, aiming to provide theoretical references for the development of S1P targeted drugs in the treatment of ALI and the search for new combined treatment schemes for ALI.

     

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