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Volume 38 Issue 12
Dec.  2022
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2022  >  38(12): 1179-1184
Shi LL,Liu MZ,Jiang ZY,et al.Research advances on pharmacological interventions for hypertrophic scar[J].Chin J Burns Wounds,2022,38(12):1179-1184.DOI: 10.3760/cma.j.cn501120-20211118-00388.
Citation: Shi LL,Liu MZ,Jiang ZY,et al.Research advances on pharmacological interventions for hypertrophic scar[J].Chin J Burns Wounds,2022,38(12):1179-1184.DOI: 10.3760/cma.j.cn501120-20211118-00388.
shu

Research advances on pharmacological interventions for hypertrophic scar

doi: 10.3760/cma.j.cn501120-20211118-00388

  • Medical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Funds:

Regional Science Fund Project of National Natural Science Foundation of China 82160376, 81960352

Key Research and Development Plan of Science and Technology Department of Jiangxi Province of China 20171ACG70004

Youth Science Foundation of Jiangxi Province of China 20192BAB215029

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    Abstract
  • Hypertrophic scar is an abnormal fibrous proliferative disease that occurs after deep cutaneous injury, which not only affects aesthetics and function but also has negative psychological effects on the patients. However, the mechanism of hypertrophic scar formation has not been fully elucidated, and its clinical treatment is complex with a high rate of recurrence and no radicle cure. Intervention based on molecular targets will likely be the future direction for the prevention and treatment of hypertrophic scar. In this article, we review the specific roles and mechanisms of drug-targeted interventions in hypertrophic scar formation, including general drugs, cytokines, immunomodulators, herbal extracts, exosomes, and nanomaterials, in the context of advances in both basic and clinical research at home and abroad.

     

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