Application and advances of nanozyme-loaded tissue engineering scaffolds in wound repair

Hao Ruinan; Ye Xilin; Xu Bolong; Sun Yun; Liu Huiyu; Rao Feng; Xue Jiajia

doi:10.3760/cma.j.cn501225-20220806-00337

Volume 39 Issue 6

Jun. 2023

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2023 > 39(6): 591-595

Zhu Zhe, Sun Yu, Zhou Hao, et al. Advances in the research of clinical treatment of hyperpigmentation and hypopigmentation after burns[J]. Chin j Burns, 2020, 36(7): 615-619. Doi: 10.3760/cma.j.cn501120-20190514-00241

Citation:

Hao RN,Ye XL,Xu BL,et al.Application and advances of nanozyme-loaded tissue engineering scaffolds in wound repair[J].Chin J Burns Wounds,2023,39(6):591-595.DOI: 10.3760/cma.j.cn501225-20220806-00337.

Citation:

Hao RN,Ye XL,Xu BL,et al.Application and advances of nanozyme-loaded tissue engineering scaffolds in wound repair[J].Chin J Burns Wounds,2023,39(6):591-595.DOI: 10.3760/cma.j.cn501225-20220806-00337.

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Application and advances of nanozyme-loaded tissue engineering scaffolds in wound repair

doi: 10.3760/cma.j.cn501225-20220806-00337

1.
State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Center of Advanced Elastomer Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
2.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, BionanomaterialsTranslational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
3.
Trauma Center, Peking University People's Hospital, National Center for Trauma Medicine, Beijing 100044, China

Funds:

Youth Science Foundation Program of National Natural Science Foundation of China 82002049

Special Funds for Fundamental Scientific Research Expenses of Central Universities buctrc202020

More Information

Corresponding author: Xue Jiajia, Email: jiajiaxue@mail.buct.edu.cn
Received Date: 2022-08-06
Available Online: 2023-06-25

Abstract

Abstract

At present, effective reconstruction of the integrity and functionality of damaged skin tissue remains an important medical problem in the field of wound repair. In recent years, the rapid development of nanozymes and tissue engineering scaffolds in the field of regenerative medicine has made it possible to develop new skin wound repair materials. Based on the process of skin wound repair and regeneration, this review briefly describes the nanozymes and its catalytic mechanism. At the same time, the common tissue engineering scaffolds loaded with nanozymes and their manufacturing strategies are introduced, the application of tissue engineering scaffolds loaded with nanozymes during the stages of anti-bacteria and anti-inflammation in the process of wound repair is summarized, and their future development direction is discussed.
- Biocompatible materials,
- Tissue engineering,
- Stents,
- Nanozymes,
- Wound repair,
- Skin regeneration

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References(37)

References

[1]	OliverS,PhamT,LiY,et al.More than skin deep: using polymers to facilitate topical delivery of nitric oxide[J].Biomater Sci,2021,9(2):391-405.DOI: 10.1039/d0bm01197e.
[2]	ZhangY,JinY,CuiH,et al.Nanozyme-based catalytic theranostics[J].RSC Adv,2019,10(1):10-20.DOI: 10.1039/c9ra09021e.
[3]	LiY,ZhuW,LiJ,et al.Research progress in nanozyme-based composite materials for fighting against bacteria and biofilms[J].Colloids Surf B Biointerfaces,2021,198:111465.DOI: 10.1016/j.colsurfb.2020.111465.
[4]	WangX , HuY , HuiW. Nanozymes in bionanotechnology: from sensing to therapeutics and beyond[J]. Inorg Chem Front, 2016, 3(1): 41-60. DOI: 10.1039/C5QI00240K.
[5]	DongH,FanY,ZhangW,et al.Catalytic mechanisms of nanozymes and their applications in biomedicine[J].Bioconjug Chem,2019,30(5):1273-1296.DOI: 10.1021/acs.bioconjchem.9b00171.
[6]	戈明亮,李越颖,梁国栋.纳米酶在传感检测中的应用研究进展[J].材料导报,2021,35(19):19195-19203.DOI: 10.11896/cldb.20060177.
[7]	WangH,WanK,ShiX.Recent advances in nanozyme research[J].Adv Mater,2019,31(45):e1805368.DOI: 10.1002/adma.201805368.
[8]	李卓轩,封开政,张薇,等.纳米酶的催化机制及应用[J].科学通报,2018,63(21):2128-2139.DOI: 10.1360/N972018-00426.
[9]	YangW, YangX, ZhuL, et al. Nanozymes: activity origin, catalytic mechanism, and biological application[J]. Coordination Chemistry Reviews, 2021, 448: 214170. DOI: 10.1016/j.ccr.2021.214170.
[10]	CelardoI,PedersenJZ,TraversaE,et al.Pharmacological potential of cerium oxide nanoparticles[J].Nanoscale,2011,3(4):1411-1420. DOI: 10.1039/c0nr00875c.
[11]	DaiY, DingY, LiL. Nanozymes for regulation of reactive oxygen species and disease therapy[J]. Chinese Chemical Letters, 2021, 32(9): 2715-2728. DOI: 10.1016/j.cclet.2021.03.036.
[12]	HaoR,CuiZ,ZhangX,et al.Rational design and preparation of functional hydrogels for skin wound healing[J].Front Chem,2021,9:839055.DOI: 10.3389/fchem.2021.839055.
[13]	周紫萱,姜耀男,肖仕初.原位成形可注射水凝胶特性及其促创面愈合作用研究进展[J].中华烧伤杂志,2021,37(1):82-85.DOI: 10.3760/cma.j.cn501120-20200428-00243.
[14]	JinX,ZhangW,ShanJ,et al.Thermosensitive hydrogel loaded with nickel-copper bimetallic hollow nanospheres with SOD and CAT enzymatic-like activity promotes acute wound healing[J].ACS Appl Mater Interfaces,2022,14(45):50677-50691.DOI: 10.1021/acsami.2c17242.
[15]	ShenJ,ChenA,CaiZ,et al.Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration[J].Bioact Mater,2022,12:153-168.DOI: 10.1016/j.bioactmat.2021.10.013.
[16]	GulA,GallusI,TegginamathA,et al.Electrospun antibacterial nanomaterials for wound dressings applications[J].Membranes (Basel),2021,11(12):908. DOI: 10.3390/membranes11120908.
[17]	GaoC,ZhangL,WangJ,et al.Electrospun nanofibers promote wound healing: theories, techniques, and perspectives[J].J Mater Chem B,2021,9(14):3106-3130.DOI: 10.1039/d1tb00067e.
[18]	HuM,KorscheltK,DanielP,et al.Fibrous nanozyme dressings with catalase-like activity for h2o2 reduction to promote wound healing[J].ACS Appl Mater Interfaces,2017,9(43):38024-38031.DOI: 10.1021/acsami.7b12212.
[19]	GaoL,ShaabaniS,Reyes RomeroA,et al.Correction: 'chemistry at the speed of sound': automated 1536-well nanoscale synthesis of 16 scaffolds in parallel[J].Green Chem,2023,25(10):4138.DOI: 10.1039/d3gc90037a.
[20]	ZhuW,ChiM,GaoM,et al.Controlled synthesis of titanium dioxide/molybdenum disulfide core-shell hybrid nanofibers with enhanced peroxidase-like activity for colorimetric detection of glutathione[J].J Colloid Interface Sci,2018,528:410-418.DOI: 10.1016/j.jcis.2018.05.068.
[21]	ChenS, ChiM, ZhuY, et al. A facile synthesis of superparamagnetic Fe3O4 nanofibers with superior peroxidase-like catalytic activity for sensitive colorimetric detection of l-cysteine[J]. Applied Surface Science, 2018, 440: 237-244. DOI: 10.1016/j.apsusc.2018.01.152.
[22]	SongW, ZhaoB, WangC, et al. Electrospun nanofibrous materials: a versatile platform for enzyme mimicking and their sensing applications[J]. Composites Communications, 2019, 12: 1-13. DOI: 10.1016/j.coco.2018.12.005.
[23]	金荣华,张珍珍,徐鹏钦,等.三维生物打印抗菌型水凝胶对大鼠全层皮肤缺损创面的作用[J].中华烧伤与创面修复杂志,2023,39(2):165-174.DOI: 10.3760/cma.j.cn501120-20210809-00274.
[24]	MihaiMM,DimaMB,DimaB,et al.Nanomaterials for wound healing and infection control[J].Materials (Basel),2019,12(13):2176.DOI: 10.3390/ma12132176.
[25]	WangQ, WeiH, ZhangZ, et al. Nanozyme: an emerging alternative to natural enzyme for biosensing and immunoassay[J]. TrAC Trends in Analytical Chemistry, 2018, 105: 218-224. DOI: 10.1016/j.trac.2018.05.012.
[26]	ChenJ,ZhangS,ChenX,et al.A self-assembled fmoc-diphenylalanine hydrogel-encapsulated pt nanozyme as oxidase- and peroxidase-like breaking pH limitation for potential antimicrobial application[J].Chemistry,2022,28(26):e202104247.DOI: 10.1002/chem.202104247.
[27]	JiaZ,LvX,HouY,et al.Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics[J].Bioact Mater,2021,6(9):2676-2687.DOI: 10.1016/j.bioactmat.2021.01.033.
[28]	LiY,WangL,LiuH,et al.Ionic covalent-organic framework nanozyme as effective cascade catalyst against bacterial wound infection[J].Small,2021,17(32):e2100756.DOI: 10.1002/smll.202100756.
[29]	SangY, LiW, LiuH, et al. Construction of nanozyme-hydrogel for enhanced capture and elimination of bacteria[J]. Advanced Functional Materials, 2019,29:1900518. DOI: 10.1002/adfm.201900518.
[30]	LiY,FuR,DuanZ,et al.Mussel-inspired adhesive bilayer hydrogels for bacteria-infected wound healing via NIR-enhanced nanozyme therapy[J].Colloids Surf B Biointerfaces,2022,210:112230.DOI: 10.1016/j.colsurfb.2021.112230.
[31]	SunD,PangX,ChengY,et al.Ultrasound-switchable nanozyme augments sonodynamic therapy against multidrug-resistant bacterial infection[J].ACS Nano,2020,14(2):2063-2076.DOI: 10.1021/acsnano.9b08667.
[32]	DickinsonBC,ChangCJ.Chemistry and biology of reactive oxygen species in signaling or stress responses[J].Nat Chem Biol,2011,7(8):504-511.DOI: 10.1038/nchembio.607.
[33]	RatherHA,ThakoreR,SinghR,et al.Antioxidative study of cerium oxide nanoparticle functionalised PCL-gelatin electrospun fibers for wound healing application[J].Bioact Mater,2017,3(2):201-211.DOI: 10.1016/j.bioactmat.2017.09.006.
[34]	TuC,LuH,ZhouT,et al.Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties[J].Biomaterials,2022,286:121597.DOI: 10.1016/j.biomaterials.2022.121597.
[35]	XiongY,ChenL,LiuP,et al.All-in-one: multifunctional hydrogel accelerates oxidative diabetic wound healing through timed-release of exosome and fibroblast growth factor[J].Small,2022,18(1):e2104229.DOI: 10.1002/smll.202104229.
[36]	WuH,LiF,ShaoW,et al.Promoting angiogenesis in oxidative diabetic wound microenvironment using a nanozyme-reinforced self-protecting hydrogel[J].ACS Cent Sci,2019,5(3):477-485.DOI: 10.1021/acscentsci.8b00850.
[37]	LiY, FuR, DuanZ, et al. Injectable hydrogel based on defect-rich multi-nanozymes for diabetic wound healing via an oxygen self-supplying cascade reaction[J]. Small, 2022, 18(18): e2200165. DOI: 10.1002/smll.202200165.

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Application and advances of nanozyme-loaded tissue engineering scaffolds in wound repair

doi: 10.3760/cma.j.cn501225-20220806-00337

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Application and advances of nanozyme-loaded tissue engineering scaffolds in wound repair

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