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Volume 40 Issue 4
Apr.  2024
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2024  >  40(4): 389-394
Zhang LX,Hu DH.Research advances on the role of aerobic glycolysis in skin fibrosis diseases[J].Chin J Burns Wounds,2024,40(4):389-394.DOI: 10.3760/cma.j.cn501225-20230712-00004.
Citation: Zhang LX,Hu DH.Research advances on the role of aerobic glycolysis in skin fibrosis diseases[J].Chin J Burns Wounds,2024,40(4):389-394.DOI: 10.3760/cma.j.cn501225-20230712-00004.
shu

Research advances on the role of aerobic glycolysis in skin fibrosis diseases

doi: 10.3760/cma.j.cn501225-20230712-00004

  • Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

Funds:

General Program of National Natural Science Foundation of China 81372069, 81772071

The First Affiliated Hospital of Air Force Medical University Discipline Boosting Program for the Military Medical Basic Research Special Project XJZT21J05

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    Abstract
  • Skin fibrosis diseases mainly include hypertrophic scar, keloid, and systemic sclerosis, etc. The main pathological features are excessive activation of fibroblasts and abnormal deposition of extracellular matrix. In recent years, studies have shown that aerobic glycolysis is closely related to the occurrence and development of skin fibrosis diseases. Drugs targeting aerobic glycolysis has provided new ideas for skin anti-fibrosis treatment. This article reviews the role of enzymes and products related to aerobic glycolysis in the occurrence and development of skin fibrosis diseases and the drugs targeting aerobic glycolysis for the treatment of skin fibrosis diseases.

     

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