Roles of hypoxia and inflammation in wound healing

Wei Zairong; Zhang Yanji; Wang Dali

doi:10.3760/cma.j.cn501225-20240111-00014

Volume 40 Issue 6

Jun. 2024

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2024 > 40(6): 507-513

Wei ZR,Zhang YJ,Wang DL.Roles of hypoxia and inflammation in wound healing[J].Chin J Burns Wounds,2024,40(6):507-513.DOI: 10.3760/cma.j.cn501225-20240111-00014.

Citation:

Wei ZR,Zhang YJ,Wang DL.Roles of hypoxia and inflammation in wound healing[J].Chin J Burns Wounds,2024,40(6):507-513.DOI: 10.3760/cma.j.cn501225-20240111-00014.

Citation:

Wei ZR,Zhang YJ,Wang DL.Roles of hypoxia and inflammation in wound healing[J].Chin J Burns Wounds,2024,40(6):507-513.DOI: 10.3760/cma.j.cn501225-20240111-00014.

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Roles of hypoxia and inflammation in wound healing

doi: 10.3760/cma.j.cn501225-20240111-00014

Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

Funds:

Regional Science Foundation Project of National Natural Science Foundation of China 82360445

Collaborative Innovation Center of Chinese Ministry of Education and Guizhou Province 2020-39

Science and Technology Plan Project of Zunyi City 2021-3

Scientific Research and Talent Training Funds of Kweichow Moutai Hospital 2022-13

More Information

Corresponding author: Wang Dali, Email: daliwangzy@sina.com
Received Date: 2024-01-11

Abstract

Abstract

Wound healing is a complex biological process. Hypoxia and inflammation are the two key factors that initiate wound healing and affect the wound healing process. Hypoxia-inducible factor-1α (HIF-1α) and nuclear factor κB are the important regulators of hypoxia and inflammation. The interaction between hypoxia and inflammation is essentially mediated by HIF-1α and nuclear factor κB signaling pathways. The abnormal expression of HIF-1α or nuclear factor κB signaling pathway caused by the imbalance of hypoxia and inflammation will affect the wound microenvironment and lead to abnormal wound healing. This paper discussed the effects of hypoxia and inflammation on wound healing, emphasized the role of cooperation between hypoxia and inflammation on wound healing and the effect of their imbalance on the quality of wound healing, summarized the current intervention strategies of hypoxia and inflammation signaling pathways, and prospected the treatment of wound in the future.
- Wound healing,
- Inflammation,
- Hypoxia,
- Hypoxia-inducible factor 1

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References(43)

References

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Roles of hypoxia and inflammation in wound healing

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