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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  >  > Accepted Manuscript
Zhu DZ,Yao B,Yan ZQ,et al.Research advances on the construction of an ideal scar model in vitro based on innovative tissue engineering technology[J].Chin J Burns Wounds,2022,38(10):983-988.DOI: 10.3760/cma.j.cn501120-20210723-00257.
Citation: Tang Yuchen,Zhang Zheng,Zhang Yixin.Clinical efficacy of the Magpie-bridge Microskin Grafting in treating fine line scars[J].Chin J Burns Wounds,2025,41(4):1-8.DOI: 10.3760/cma.j.cn501225-20250213-00057.
shu

Clinical efficacy of the Magpie-bridge Microskin Grafting in treating fine line scars

doi: 10.3760/cma.j.cn501225-20250213-00057

  • Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Funds:

General Program of National Natural Science Foundation of China 82172222, 82272266

Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support 20152227

More Information
  • Corresponding author: Zhang Yixin, Email: zhangyixin6688@163.com
  • Received Date: 2025-02-13
    Available Online: 2025-04-02
    Abstract
  •   Objective  To evaluate the clinical efficacy of the Magpie-bridge Microskin Grafting (hereinafter briefly referred to as Magpie-bridge surgery) in treating fine line scars (FLS).  Methods  This study was a retrospective cohort study. From October 2022 to December 2023, 37 FLS patients treated with the Magpie-bridge surgery at the Department of Plastic and Reconstructive Surgery of Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, including 9 males and 28 females, aged 25 (17, 36) years. All scars were <2 mm in width and 1–10 cm in length before surgery. An electric dermatome was used to excise scar tissue at intervals to form wounds and harvest microskin grafts of the same size and thickness as the removed scar tissue from behind the ear or armpit top area. The microskin grafts were implanted at the wound sites and fixed with tension reducing adhesive tape. The donor areas were treated with normal dressing change. Twelve months after the first surgery, the efficacy based on the degree of reduction in scar white area compared with that before the first surgery was evaluated, and the treatment effectiveness rate was calculated. Before the first surgery and 12 months after the first surgery, the melanin score of the scar area and the surrounding normal skin area was evaluated through a skin imaging analysis system, and the melanin score difference between the surrounding normal skin area of scar and the scar area was calculated. The white scar tissue that was not removed during the first surgery (hereinafter referred to as untreated scar tissue) and tissue from the site of scar removal and microskin transplantation at 12 months after surgery (hereinafter referred to as the recipient skin tissue at 12 months after the first surgery) were collected from 6 patients of the aforementioned group seeking better therapeutic outcomes. The tissue structure, melanin quantity and distribution were observed by hematoxylin eosin staining and Masson-Fontana staining, and the activity of tyrosinase positive melanocytes was observed by immunofluorescence staining.  Results  At 12 months after the first surgery, the efficacy evaluation results showed that 24 cases were cured, 11 cases improved, and respectively 1 case was ineffective or the condition worsened, yielding a 94.6% (35/37) treatment effectiveness rate. The melanin score difference between the surrounding normal skin area of scar and the scar area was 0.45 (0.10, 1.65) at 12 months after the first surgery, which was significantly less than 2.50 (1.40, 5.96) before the first surgery (Z=-5.02, P<0.05). Six patients had untreated scar tissue with flat epidermis and a flat junction between dermis and epidermis; the collagen fiber bundles in the dermis were thick and single parallel; no hair follicles or other skin appendages were observed; the basal layer of the epidermis showed deposition of melanin particles, but no extensive depigmentation was observed. Compared with those of untreated scar tissue, the epidermal thickness increased, and epidermal protrusions appeared at the junction of dermis and epidermis of the recipient skin tissue at 12 months after the first surgery; hair follicles and sebaceous gland appendages were visible, and collagen fibers in the dermis were arranged vertically and horizontally in an orderly manner; the basal layer of the epidermis showed deposition of melanin particles, and the melanin content increased per unit area of tissue. Tyrosinase positive melanocytes mainly located at the basal layer of the epidermis in untreated scar tissue and in the recipient skin tissue 12 months after the first surgery, with normal cell activity and no significant difference.  Conclusions  It is confirmed by subjective and objective indicators that the Magpie-bridge surgery can significantly improve the appearance of FLS in patients, with definite therapeutic effects and clinical promotion value; the improvement of FLS appearance by Magpie-bridge surgery may be related to the increase of melanin content per unit area and the normalization of tissue structure.

     

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