Advances in the research of acute kidney injury post burn

Acute kidney injury (AKI), one of the common and important complications post burn, shows a high incidence and mortality in severely burned patients. The common etiologic factors involved in the development of AKI post burn include hypovolaemia, denatured proteins, nephrotoxic agents, etc., while the molecular mechanisms include oxidative stress injury, systematic or local inflammation, apoptosis, and so on. Furthermore, quite a few signaling pathways participate in the regulation of the occurrence and development of AKI post burn. Existed researches on the treatment of AKI post burn focus on the fluid replacement, renal replacement therapy, anti-infection, and specific agents interfering pathophysiologic or molecular mechanisms of AKI. In this review, we summarize the new advances in the research of the occurrence, development, and diagnosis and treatment of AKI post burn.