Advances in the research of effects of circulating fibroblasts on wound repair

Wound repair is a complex process involving multiple disciplines, cell factors, cell types, and signaling pathways. In recent years, many researches showed that circulating fibroblasts (cFbs) deriving from bone marrow and residing in peripheral blood, played a role in wound repair by migrating to wound sites, differentiating into fibroblasts and myofibroblasts, and secreting cytokines, extracellular matrix, chemokines, growth factors, and antigen-presenting molecules, etc. cFbs also involve in three phases of inflammation, proliferation, and remodeling in wound repair of diabetes, ulcers, burns and other wounds, which indicate that they could be a potential treatment for wound repair. This article aims to review the latest development in circulating fibroblasts and wound repair.