Research advances on platelet-rich blood products combined with biological materials in wound repair
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摘要:
创面的有效处理是当前研究的重点,除了常规的管理和必要的手术,促愈合药物在创面治疗中的作用也逐渐被重视。富含多种生物活性分子的富血小板血液制品被认为是一种低成本且安全的促进组织愈合的治疗方式,在再生医学领域极具发展前景。然而,其因缺乏标准的制备和管理,且所含生物分子的活性不稳定,导致治疗效果参差不齐。为了解决这些问题,近年来借助生物材料保护和传递富血小板血液制品中生物活性分子的相关研究逐渐增多,这也是创面治疗的研究趋势之一。本文首先简要介绍富血小板血液制品的类型,随后概述其联合生物材料所取得的最新进展,最后总结这种联合方法在创面治疗中的研究进展与未来研究方向。
Abstract:The efficient management of wounds is the focus of current research. In addition to conventional wound management and necessary surgery, the role of pro-healing drugs in wound treatment has gradually been emphasized. Platelet-rich blood products that is rich in a variety of biologically active molecules are considered as a low-cost and safe therapy in promoting tissue healing, and have great development prospects in the field of regenerative medicine. However, due to the lack of standard preparation and management and the unstable activities of the biomolecules in them, the therapeutic effects of platelet-rich blood products are uneven. In order to solve these problems, researches related to the protection and delivery of biologically active molecules in platelet-rich blood products by biomaterials have gradually increased in recent years, which is also one of the latest trends in wound treatment research. This article first briefly introduces the types of platelet-rich blood products, then outlines the latest research progress achieved by their combination with biomaterials, and finally summarizes the research progress and future research directions of the combination approach in wound treatment.
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Key words:
- Wound healing /
- Platelet-rich plasma /
- Biocompatible materials /
- Regenerative medicine
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