胆碱能炎症反射与炎症消退研究进展

陈卓; 何骁; 姚孟维; 李战; 徐祥

doi:10.3760/cma.j.cn501120-20200609-00299

胆碱能炎症反射与炎症消退研究进展

doi: 10.3760/cma.j.cn501120-20200609-00299

陈卓¹,
何骁²,
姚孟维³,
李战³,
徐祥^3, ,

1.
陆军军医大学（第三军医大学）基础医学院，重庆　　400038
2.
火箭军特色医学中心，　北京　　100088
3.
陆军特色医学中心干细胞与再生医学科，重庆　　400042

基金项目:

国家自然科学基金青年科学基金 81801585

重庆市教育委员会新冠病毒感染与防治应急专项 KYYJ202009

陆军军医大学军事预研项目 2019XYY21

国家自然科学基金青年科学基金 81501666

详细信息

通讯作者:
徐祥，Email：xiangxu@tmmu.edu.cn

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出版历程
- 收稿日期: 2020-06-09

Research advances on the cholinergic inflammatory reflex and inflammation resolution

Chen Zhuo¹,
He Xiao²,
Yao Mengwei³,
Li Zhan³,
Xu Xiang^{3
, ,}

1.
Basic Medical School of Army Medical University (the Third Military Medical University), Chongqing 400038, China
2.
Rocket Force Characteristic Medical Center, Beijing 100088, China
3.
Department of Stem Cell and Regenerative Medicine, Army Medical Center of PLA, Chongqing 400042, China

Funds:

Youth Science Foundation of National Natural Science Foundation of China 81801585

Emergency Special Project of 2019 Novel Coronavirus Infection and Prevention and Control of Chongqing Education Commission of China KYYJ202009

Military Pre-research Project of Army Medical University 2019XYY21

Youth Science Foundation of National Natural Science Foundation of China 81501666

More Information

Corresponding author: Xu Xiang, Email: xiangxu@tmmu.edu.cn

摘要

摘要: 迷走神经在调节全身的炎症稳态中起着重要作用。体内的炎症信号经由神经反射传递给迷走神经传出纤维，后者产生的信号通过巨噬细胞、表达胆碱乙酰转移酶的T细胞等免疫细胞在各种炎症疾病中发挥抑炎作用。但是炎症的解决不仅仅是促炎性细胞因子与抗炎细胞因子的相互角力，更是一个生物合成的主动过程，其中包括各种促分解介质的合成以及它们的生理效用过程。此外，胆碱能炎症反射在炎症消退过程中同样发挥着重要作用。本综述回顾并总结了胆碱能炎症反射及其在炎症消退过程中的重要作用。
- 炎症 /
- 迷走神经 /
- 胆碱能炎症反射 /
- 炎症消退 /
- 特异性促炎症消退介质
Abstract: The vagus nerve plays an important role in regulating the homeostasis of inflammation. Inflammation signals in the body are passed to the vagus nerve efferent fibers via nerve reflexes, and the signals generated by efferent fibers will play an anti-inflammatory role in various inflammatory diseases through immune cells such as T cells that express choline acetyltransferase and macrophages. However, the resolution of inflammation is not only the interaction between pro-inflammatory and anti-inflammatory cytokines, but also an active process of biosynthesis, including the synthesis of various pro-resolving mediators and their physiological utility process. Moreover, the cholinergic inflammation reflex also plays a crucial role in inflammation resolution. This review reviews and summarizes the cholinergic inflammatory reflex and its key role in the process of inflammation resolution.
- Inflammation /
- Vagus nerve /
- Cholinergic inflammation reflex /
- Inflammation resolution /
- Specialized pro-resolving mediators
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所有作者均声明不存在利益冲突

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·消息·

2021“银领新生泰”复杂疑难创面案例大赛在青海西宁成功举行

近日，由《中华烧伤杂志》和德国保赫曼贸易有限公司联合主办的“银领新生泰”复杂疑难创面案例大赛决赛，在青海西宁成功举办。本次决赛邀请中华医学会烧伤外科学分会主任委员吕国忠教授、深圳大学第一附属医院吴军教授、空军军医大学第一附属医院胡大海教授、陆军军医大学第一附属医院彭毅志教授、空军军医大学第一附属医院官浩教授、青海大学附属医院晁生武教授以及德国保赫曼中国区董事总经理王国阳作为大赛评委。

本次大赛共收到117个高难度案例，经过前期激烈的海选赛、区域赛，来自上海交通大学医学院附属瑞金医院、江南大学附属医院（无锡市第三人民医院）、北部战区总医院、遵义医科大学附属医院等医院7位参赛选手的案例成功进入决赛。7位评委专家从伤口评估、处理策略、疑难程度等方面进行现场评分。最终，来自遵义医科大学附属医院的黄广涛提交的《一例CO中毒烧伤所致严重毁损创面的修复》案例，获得了评委专家的一致赞赏，荣获大赛一等奖。

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1 炎症反射流程图

注：IL-1为白细胞介素1，TNF为肿瘤坏死因子，LPS为内毒素/脂多糖，α7 nAchR为α7烟碱型乙酰胆碱受体，β2AR为β2肾上腺素受体

下载: 全尺寸图片幻灯片

2 迷走神经通过多种方式与特异性促炎症消退介质（SPM）相互作用

下载: 全尺寸图片幻灯片

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