自戕性肺损伤的机制和防治研究进展

任志国; 朱峰

doi:10.3760/cma.j.cn501120-20200610-00302

自戕性肺损伤的机制和防治研究进展

doi: 10.3760/cma.j.cn501120-20200610-00302

任志国¹,
朱峰^2, ,

1.
解放军海军第971医院呼吸内科，青岛　　266071
2.
海军军医大学第一附属医院烧伤外科，上海　　200433

基金项目:

国家重点研发计划“干细胞及转化研究”重点专项 2019YFA0110601

长海医院教学研究与改革重点项目 CHJG2019002

详细信息

通讯作者:
朱峰，Email：alexzhujunchi@hotmail.com

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- 被引次数: 0
出版历程
- 收稿日期: 2020-06-10

Research advances on the mechanisms and prevention and treatment of patient self-inflicted lung injury

Ren Zhiguo¹,
Zhu Feng^{2
, ,}

1.
Department of Respiratory Medicine, No 971 Hospital of PLAN, Qingdao 266071, China
2.
Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China

Funds:

National Key Research and Development Program "Stem Cell and Transformation Research" Key Special Project of China 2019YFA0110601

Key Projects of Teaching Research and Reform in Changhai Hospital CHJG2019002

More Information

Corresponding author: Zhu Feng, Email: alexzhujunchi@hotmail.com

摘要

摘要: 研究显示，因过度自主呼吸努力引起的肺损伤，即患者自戕性肺损伤（patient self-inflicted lung injury，P-SILI），是具有强烈自主呼吸的行机械通气的急性呼吸窘迫综合征（ARDS）患者发生机械通气相关性肺损伤、机械通气相关性膈肌功能障碍的重要表现形式和可能机制。本文综述了P-SILI概念、潜在发生机制、临床意义和防治等，以期为临床ARDS管理提供更多思路。
- 呼吸窘迫综合征，成人 /
- 呼吸机所致肺损伤 /
- 自戕性肺损伤 /
- 自主呼吸 /
- 呼吸努力
Abstract: Researches have shown that lung injury due to excessive spontaneous breathing effort, that is, patient self-inflicted lung injury (P-SILI), may be the important manifestation and possible mechanism of ventilation-associated lung injury and ventilation-induced diaphragmatic dysfunction in acute respiratory distress syndrome (ARDS) patients who were mechanically ventilated with intense spontaneous breathing. This paper reviews the concept of P-SILI, possible occurrence mechanism, clinical significance, and prevention and treatment, in order to provide more ideas for clinical ARDS management.
- Respiratory distress syndrome, adult /
- Ventilator-induced lung injury /
- Patient self-inflicted lung injury /
- Spontaneous breathing /
- Respiratory effort
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参考文献(33)

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