水凝胶敷料对糖尿病足创面的促愈合作用研究进展

陈跃华; 徐俊; 徐兰举; 张琳; 刘祥胜; 王淑芳

doi:10.3760/cma.j.cn501120-20200827-00393

水凝胶敷料对糖尿病足创面的促愈合作用研究进展

doi: 10.3760/cma.j.cn501120-20200827-00393

1.
南开大学生命科学学院生物活性材料教育部重点实验室，天津　　300071
2.
天津医科大学朱宪彝纪念医院糖尿病足科，天津　　300134
3.
南开大学医学院，天津　　300071

基金项目:

国家重点研发计划 2017YFC1103504

国家自然科学基金面上项目 81671842, 31870966

详细信息

通讯作者:
王淑芳，Email：wangshufang@nankai.edu.cn

计量
- 文章访问数: 785
- HTML全文浏览量: 93
- PDF下载量: 200
- 被引次数: 0
出版历程
- 收稿日期: 2020-08-27

Research advances on the promotive healing effect of hydrogel dressing for diabetic foot wound

1.
Key Laboratory of Bioactive Materials for Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China
2.
Department of Diabetic Podiatry, Chu Hisen-I Memorial Hospital, Tianjin Medical University, Tianjin 300134, China
3.
Medical College of Nankai University, Tianjin 300071, China

Funds:

National Key Research and Development Program of China 2017YFC1103504

General Program of National Natural Science Foundation of China 81671842, 31870966

More Information

Corresponding author: Wang Shufang, Email: wangshufang@ nankai.edu.cn

摘要

摘要: 近年来，糖尿病患者人数逐渐增加，发生糖尿病足患者人数也随之增加。糖尿病足具有较高的致残率和致死率，严重影响患者的生活质量，既缩短预期寿命，又带来沉重的社会负担。糖尿病足目前的治疗方法存在不足，组织工程的理念与方法为糖尿病足的治疗提供了新的思路和手段。本文介绍了糖尿病足的发病机制、导致糖尿病足创面难愈合的因素、用于治疗糖尿病足创面的功能性水凝胶敷料，以及功能性水凝胶敷料用于治疗糖尿病动物皮肤创面的技术方法，并对治疗糖尿病足创面的功能性水凝胶敷料未来发展方向进行了展望。
- 糖尿病足 /
- 组织工程 /
- 水凝胶 /
- 创伤敷料 /
- 创面愈合
Abstract: In recent years, the number of diabetic patients has gradually increased, and the number of patients with diabetic foot has also increased. Diabetic foot has a high rate of disability and death, seriously affects the patients' quality of life, shortens life expectancy, and brings heavy social burden. The current treatment methods for diabetic foot are insufficient. The concepts and methods of tissue engineering provide new thoughts and means for the treatment of diabetic foot. This article introduces the pathogenesis of diabetic foot wounds, the factors leading to non-healing of diabetic foot, the applications of functional hydrogel dressings in the treatment of diabetic foot and their technical methods of functional hydrogel dressings for treating skin wounds in diabetic animals, and the future development direction of functional hydrogel dressing for treating diabetic foot wounds is prospected.
- Diabetic foot /
- Tissue engineering /
- Hydrogel /
- Wound dressing /
- Wound healing
所有作者均声明不存在利益冲突

HTML全文

参考文献(43)

[1]	ChoNH,ShawJE,KarurangaS,et al.IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045[J].Diabetes Res Clin Pract,2018,138:271-281.DOI: 10.1016/j.diabres.2018.02.023.
[2]	WangL,GaoP,ZhangM,et al.Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013[J].JAMA,2017,317(24):2515-2523.DOI: 10.1001/jama.2017.7596.
[3]	SinghN,ArmstrongDG,LipskyBA.Preventing foot ulcers in patients with diabetes[J].JAMA,2005,293(2):217-228.DOI: 10.1001/jama.293.2.217.
[4]	GrigoropoulouP,EleftheriadouI,JudeEB,et al.Diabetic foot infections: an update in diagnosis and management[J].Curr Diab Rep,2017,17(1):3.DOI: 10.1007/s11892-017-0831-1.
[5]	ArmstrongDG,BoultonA,BusSA.Diabetic foot ulcers and their recurrence[J].N Engl J Med,2017,376(24):2367-2375.DOI: 10.1056/NEJMra1615439.
[6]	BowlingFL,RashidST,BoultonAJ.Preventing and treating foot complications associated with diabetes mellitus[J].Nat Rev Endocrinol,2015,11(10):606-616.DOI: 10.1038/nrendo.2015.130.
[7]	GuptaSK,SinghSK.Diabetic foot: a continuing challenge[J].Adv Exp Med Biol,2012,771:123-138.
[8]	LimJZ,NgNS,ThomasC.Prevention and treatment of diabetic foot ulcers[J].J R Soc Med,2017,110(3):104-109.DOI: 10.1177/0141076816688346.
[9]	HanG,CeilleyR.Chronic wound healing: a review of current management and treatments[J].Adv Ther,2017,34(3):599-610.DOI: 10.1007/s12325-017-0478-y.
[10]	CavanaghPR.Therapeutic footwear for people with diabetes[J].Diabetes Metab Res Rev,2004,20 Suppl 1:S51-55.DOI: 10.1002/dmrr.435.
[11]	HuangC,LeavittT,BayerLR,et al.Effect of negative pressure wound therapy on wound healing[J].Curr Probl Surg,2014,51(7):301-331.DOI: 10.1067/j.cpsurg.2014.04.001.
[12]	SinghVP,BaliA,SinghN,et al.Advanced glycation end products and diabetic complications[J].Korean J Physiol Pharmacol,2014,18(1):1-14.DOI: 10.4196/kjpp.2014.18.1.1.
[13]	BlakytnyR,JudeEB.Altered molecular mechanisms of diabetic foot ulcers[J].Int J Low Extrem Wounds,2009,8(2):95-104.DOI: 10.1177/1534734609337151.
[14]	FalangaV.Wound healing and its impairment in the diabetic foot[J].Lancet,2005,366(9498):1736-1743.DOI: 10.1016/S0140-6736(05)67700-8.
[15]	HeubleinH,BaderA,GiriS.Preclinical and clinical evidence for stem cell therapies as treatment for diabetic wounds[J].Drug Discov Today,2015,20(6):703-717.DOI: 10.1016/j.drudis.2015.01.005.
[16]	VevesA,GiuriniJM,GuzmanRJ.The diabetic foot: medical and surgical management[M]//Giatsidis G,Orgill DP,Yannas IV.Dermal regeneration and induction of wound closure in diabetic wounds. Cham: Springer International Publishing,2018:155-172.
[17]	LeeKY,MooneyDJ.Hydrogels for tissue engineering[J].Chem Rev,2001,101(7):1869-1879.DOI: 10.1021/cr000108x.
[18]	GrunfeldC.Diabetic foot ulcers: etiology, treatment, and prevention[J].Adv Intern Med,1992,37:103-132.
[19]	LangerR,VacantiJP.Tissue engineering[J].Science,1993,260(5110):920-926.DOI: 10.1126/science.8493529.
[20]	OhJK,SiegwartDJ,LeeHI,et al.Biodegradable nanogels prepared by atom transfer radical polymerization as potential drug delivery carriers: synthesis, biodegradation, in vitro release, and bioconjugation[J].J Am Chem Soc,2007,129(18):5939-5945.DOI: 10.1021/ja069150l.
[21]	BessmanAN,SapicoFL.Infections in the diabetic patient: the role of immune dysfunction and pathogen virulence factors[J].J Diabetes Complications,1992,6(4):258-262.DOI: 10.1016/1056-8727(92)90062-p.
[22]	AbbasM,UçkayI,LipskyBA.In diabetic foot infections antibiotics are to treat infection, not to heal wounds[J].Expert Opin Pharmacother,2015,16(6):821-832.DOI: 10.1517/14656566.2015.1021780.
[23]	GemechuFW,SeemantF,CurleyCA.Diabetic foot infections[J].Am Fam Physician,2013,88(3):177-184.
[24]	da SilvaLP,ReisRL,CorreloVM,et al.Hydrogel-based strategies to advance therapies for chronic skin wounds[J].Annu Rev Biomed Eng,2019,21:145-169.DOI: 10.1146/annurev-bioeng-060418-052422.
[25]	Malone-PovolnyMJ,MaloneySE,SchoenfischMH.Nitric oxide therapy for diabetic wound healing[J].Adv Healthc Mater,2019,8(12):e1801210.DOI: 10.1002/adhm.201801210.
[26]	WangX,ChengF,LiuJ,et al.Biocomposites of copper-containing mesoporous bioactive glass and nanofibrillated cellulose: biocompatibility and angiogenic promotion in chronic wound healing application[J].Acta Biomater,2016,46:286-298.DOI: 10.1016/j.actbio.2016.09.021.
[27]	LiXX,DongJY,LiYH,et al.Fabrication of Ag-ZnO@ carboxymethyl cellulose/K-carrageenan/grapheme oxide/konjac glucomannan hydrogel for effective wound dressing in nursing care for diabetic foot ulcers[J].Appl Nanosci, 2020,10(3):729-738.DOI: 10.1007/s13204-019-01194-z.
[28]	ChenH,ChengRY,ZhaoX,et al.An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair[J].NPG Asia Mater,2019,11:3.DOI: 10.1038/s41427-018-0103-9.
[29]	ZhaoY,LiZH,SongSL,et al.Skin-inspired antibacterial conductive hydrogels for epidermal sensors and diabetic foot wound dressings[J].Adv Funct Mater,2019,29(31):1901474.DOI: 10.1002/adfm.201901474.
[30]	DiPietroLA.Angiogenesis and wound repair: when enough is enough[J].J Leukoc Biol,2016,100(5):979-984.DOI: 10.1189/jlb.4MR0316-102R.
[31]	ChellappanDK,YeneseY,WeiCC,et al.Nanotechnology and diabetic wound healing: a review[J].Endocr Metab Immune Disord Drug Targets,2017,17(2):87-95.DOI: 10.2174/1871530317666170421121202.
[32]	ZhuY,HoshiR,ChenS,et al.Sustained release of stromal cell derived factor-1 from an antioxidant thermoresponsive hydrogel enhances dermal wound healing in diabetes[J].J Control Release,2016,238:114-122.DOI: 10.1016/j.jconrel.2016.07.043.
[33]	XiaoJ,ChenS,YiJ,et al.A cooperative copper metal-organic framework-hydrogel system improves wound healing in diabetes[J].Adv Funct Mater,2017,27(1):1604872.DOI: 10.1002/adfm.201604872.
[34]	YoonDS,LeeY,RyuHA,et al.Cell recruiting chemokine-loaded sprayable gelatin hydrogel dressings for diabetic wound healing[J].Acta Biomater,2016,38:59-68.DOI: 10.1016/j.actbio.2016.04.030.
[35]	ZhangL,MaY,PanX,et al.A composite hydrogel of chitosan/heparin/poly (γ-glutamic acid) loaded with superoxide dismutase for wound healing[J].Carbohydr Polym,2018,180:168-174.DOI: 10.1016/j.carbpol.2017.10.036.
[36]	XuZ,HanS,GuZ,et al.Advances and impact of antioxidant hydrogel in chronic wound healing[J].Adv Healthc Mater,2020,9(5):e1901502.DOI: 10.1002/adhm.201901502.
[37]	LiuJ,ChenZ,WangJ,et al.Encapsulation of curcumin nanoparticles with MMP9-responsive and thermos-sensitive hydrogel improves diabetic wound healing[J].ACS Appl Mater Interfaces,2018,10(19):16315-16326.DOI: 10.1021/acsami.8b03868.
[38]	HuP,YangQ,WangQ,et al.Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration[J/OL].Burns Trauma,2019,7:38[2020-08-27]. https://pubmed.ncbi.nlm.nih.gov/31890717/.DOI: 10.1186/s41038-019-0178-8.
[39]	da SilvaLP,SantosTC,RodriguesDB,et al.Stem cell-containing hyaluronic acid-based spongy hydrogels for integrated diabetic wound healing[J].J Invest Dermatol,2017,137(7):1541-1551.DOI: 10.1016/j.jid.2017.02.976.
[40]	WangM,WangCG,ChenM,et al.Efficient angiogenesis-based diabetic wound healing/skin reconstruction through bioactive antibacterial adhesive ultraviolet shielding nanodressing with exosome release[J].ACS Nano,2019,13(9):10279-10293.DOI: 10.1021/acsnano.9b03656.
[41]	ZhaoL,NiuL,LiangH,et al.pH and glucose dual-responsive injectable hydrogels with insulin and fibroblasts as bioactive dressings for diabetic wound healing[J].ACS Appl Mater Interfaces,2017,9(43):37563-37574.DOI: 10.1021/acsami.7b09395.
[42]	WangS,ZhengH,ZhouL,et al.Nanoenzyme-reinforced injectable hydrogel for healing diabetic wounds infected with multidrug resistant bacteria[J].Nano Lett,2020,20(7):5149-5158.DOI: 10.1021/acs.nanolett.0c01371.
[43]	ZhuYN,ZhangJM,SongJY,et al.A multifunctional pro-healing zwitterionic hydrogel for simultaneous optical monitoring of pH and glucose in diabetic wound treatment[J].Adv Funct Mater,2020,30(6):1905493. DOI: 10.1002/adfm.201905493.