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竞争性内源性RNA在创面愈合中作用的研究进展

廖银友 张丕红

廖银友, 张丕红. 竞争性内源性RNA在创面愈合中作用的研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(1): 84-89. DOI: 10.3760/cma.j.cn501120-20201125-00498.
引用本文: 廖银友, 张丕红. 竞争性内源性RNA在创面愈合中作用的研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(1): 84-89. DOI: 10.3760/cma.j.cn501120-20201125-00498.
Liao YY,Zhang PH.Research advances on the role of competing endogenous RNAs in wound healing[J].Chin J Burns Wounds,2022,38(1):84-89.DOI: 10.3760/cma.j.cn501120-20201125-00498.
Citation: Liao YY,Zhang PH.Research advances on the role of competing endogenous RNAs in wound healing[J].Chin J Burns Wounds,2022,38(1):84-89.DOI: 10.3760/cma.j.cn501120-20201125-00498.

竞争性内源性RNA在创面愈合中作用的研究进展

doi: 10.3760/cma.j.cn501120-20201125-00498
基金项目: 

国家自然科学基金面上项目 81772084

详细信息
    通讯作者:

    张丕红,Email:zphong@aliyun.com

Research advances on the role of competing endogenous RNAs in wound healing

Funds: 

General Program of National Natural Science Foundation of China 81772084

More Information
  • 摘要: 创面愈合作为重要的公共卫生问题之一,一直是世界性难题。由于独特的生物创面环境,创面愈合是一个非常复杂的过程,目前治疗周期长、疗效欠佳,患者经济负担重。越来越多的研究表明,非编码RNA(ncRNA)在创面愈合过程中扮演着重要角色。竞争性内源性RNA(ceRNA)假说是近些年新提出的一种RNA相互调控假说,该假说提出了不同RNA之间的一种“交流方式”。ceRNA调控网络(ceRNET)将蛋白质编码mRNA的功能与ncRNA(如微小RNA、长链非编码RNA、假基因和环状RNA)的功能联系起来。最新的研究表明,ceRNA在创面愈合过程中发挥重要作用,这可能为创面愈合提供新的有效治疗靶标。本文从ceRNET着手,系统综述各种ceRNA在创面愈合中的作用研究进展及未来研究的挑战,旨在深入探究ceRNA在创面愈合过程中的分子机制及临床意义。

     

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  • 收稿日期:  2020-11-25

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