The iatrogenic wound is defined as infection, necrosis, or defect of the skin and deep soft tissue resulting from a medical procedure. At present, the main factors causing iatrogenic wounds include surgery, radiotherapy, interventional therapy, and drugs etc. Iatrogenic wounds are attributed to iatrogenic injuries that are in accordance with ethics, laws, and relevant regulations, and the degree of these injuries is within an acceptable range. Medical staff can reduce the incidence of iatrogenic wounds and the degree of injury by improving medical technology and responsibility in medical procedures. Iatrogenic wounds can be repaired and the patient's physical and mental health can be restored with targeted medical treatment. How to effectively prevent and treat iatrogenic wounds so as to minimize the degree of iatrogenic injuries to patients needs further exploration. To sum up, the purpose to publish this special topic in this issue is to arouse the peer's attention to the prevention and treatment of iatrogenic wounds.