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摘要: 随着人口老龄化和社会经济的发展，慢性创面发病率日益增高，同时烧创伤发病率仍处于较高水平，使得创面修复成为临床日益关注的领域。胸腺素β4是一种体内天然存在的小分子蛋白，其广泛分布于多种体液和细胞内，尤其是血小板中。胸腺素β4具有促进血管生成、抗炎、抗凋亡及抗纤维化的生物活性，在创面修复方面有许多重要的功能。目前已经在烧伤、糖尿病溃疡、压疮等多种创面中观察到胸腺素β4具有促进愈合的作用。该文将从胸腺素β4的分子结构、促创面愈合作用机制、药代动力学及临床应用方面进行综述，旨在介绍该因子在创面治疗中的潜力和当前研究的不足之处。Abstract: With the aging of population and the development of social economy, the incidence of chronic wounds is increasing day by day, while the incidence of burns and trauma remains at a high level, making wound repair an increasingly concerned area in clinical practice. Thymosin β4 is a naturally occurring small molecule protein in vivo, which is widely distributed in a variety of body fluids and cells, especially in platelets. Thymosin β4 has biological activities of promoting angiogenesis, anti-inflammation, anti-apoptosis, and anti-fibrosis, and has many important functions in wound repair. Thymosin β4 has been observed to promote the healing of various wounds, such as burns, diabetic ulcers, pressure ulcers. This paper will review the molecular structure, mechanism of wound healing promotion, pharmacokinetics, and clinical application of thymosin β4, aiming to introduce its potential in wound treatment and the shortcomings of current researches.
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Key words:
- Wound healing /
- Thymosin /
- Mechanism of action /
- Clinical application
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1 胸腺素β4的氨基酸序列示意图
注：图中S、D、K、P等小球分别代表丝氨酸、天冬氨酸、赖氨酸、脯氨酸等氨基酸；从最左S开始，已知的胸腺素β4的4个生物活性位点位于第1~4位氨基酸、第1~15位氨基酸、第17~23位氨基酸、最末4位氨基酸
2 胸腺素β4在创面凝血、炎症、增生阶段的作用机制
注：IL-1为白细胞介素1，TNF-α为肿瘤坏死因子α，Bcl-2为B淋巴细胞瘤-2，Bax为Bcl-2相关X蛋白，iNOS为诱导型一氧化氮合酶
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