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不良饮食习惯影响瘢痕疙瘩形成的研究进展

徐琦 刘伟

徐琦, 刘伟. 不良饮食习惯影响瘢痕疙瘩形成的研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(4): 389-393. DOI: 10.3760/cma.j.cn501120-20210401-00112.
引用本文: 徐琦, 刘伟. 不良饮食习惯影响瘢痕疙瘩形成的研究进展[J]. 中华烧伤与创面修复杂志, 2022, 38(4): 389-393. DOI: 10.3760/cma.j.cn501120-20210401-00112.
Xu Q,Liu W.Research advances on the influence of poor dietary habits on the development of keloids[J].Chin J Burns Wounds,2022,38(4):389-393.DOI: 10.3760/cma.j.cn501120-20210401-00112.
Citation: Xu Q,Liu W.Research advances on the influence of poor dietary habits on the development of keloids[J].Chin J Burns Wounds,2022,38(4):389-393.DOI: 10.3760/cma.j.cn501120-20210401-00112.

不良饮食习惯影响瘢痕疙瘩形成的研究进展

doi: 10.3760/cma.j.cn501120-20210401-00112
基金项目: 

国家自然科学基金面上项目 81671921

详细信息
    通讯作者:

    刘伟,Email:liuwei_md@126.com

Research advances on the influence of poor dietary habits on the development of keloids

Funds: 

General Program of National Natural Science Foundation of China 81671921

More Information
    Corresponding author: Liu Wei, Email: liuwei_md@126.com
  • 摘要: 长期的不良饮食习惯可造成肠道菌群改变,使得内毒素/脂多糖大量生成,导致肠道黏膜通透性增加,激活大量炎症因子进入门静脉。此外,高碳水化合物饮食可增加肝脏代谢负担,促进线粒体氧化磷酸化,导致氧化应激,在ATP合成过程中产生新的脂肪,从而导致脂肪异位堆积,激活核因子κB信号通路,释放肿瘤坏死因子α、白细胞介素1β(IL-1β)和IL-6等炎症因子,导致肥胖和胰岛素抵抗,最终引发系统性低度炎症。该综述回顾了不良饮食习惯导致系统性低度炎症的机制、瘢痕疙瘩与系统性低度炎症的临床研究与实验研究进展、饮食习惯与瘢痕疙瘩体质的关联性,提出了不良饮食习惯可能导致瘢痕疙瘩发生与发展的假说。

     

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  • 1  高碳水化合物与高脂饮食习惯导致系统性低度炎症的机制

    注:IL为白细胞介素,MCP-1为单核细胞趋化蛋白1,TNF-α为肿瘤坏死因子α,JNK为c-Jun氨基端激酶,ATP为腺苷三磷酸,LPS为内毒素/脂多糖,TLR为Toll样受体,NOD2为核苷酸结合寡聚化结构域2

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  • 收稿日期:  2021-04-01

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