不良饮食习惯影响瘢痕疙瘩形成的研究进展

徐琦; 刘伟

doi:10.3760/cma.j.cn501120-20210401-00112

不良饮食习惯影响瘢痕疙瘩形成的研究进展

doi: 10.3760/cma.j.cn501120-20210401-00112

徐琦,
刘伟^,

1.
潍坊医学院整形外科研究所，潍坊　　261042
2.
上海交通大学医学院附属第九人民医院整复外科，上海市组织工程研究重点实验室，上海　　200011

基金项目:

国家自然科学基金面上项目 81671921

详细信息

通讯作者:
刘伟，Email：liuwei_md@126.com

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出版历程
- 收稿日期: 2021-04-01

Research advances on the influence of poor dietary habits on the development of keloids

Xu Qi,
Liu Wei^,

1.
Institute of Plastic Surgery, Weifang Medical University, Weifang 261042, China
2.
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Funds:

General Program of National Natural Science Foundation of China 81671921

More Information

Corresponding author: Liu Wei, Email: liuwei_md@126.com

摘要

摘要: 长期的不良饮食习惯可造成肠道菌群改变，使得内毒素/脂多糖大量生成，导致肠道黏膜通透性增加，激活大量炎症因子进入门静脉。此外，高碳水化合物饮食可增加肝脏代谢负担，促进线粒体氧化磷酸化，导致氧化应激，在ATP合成过程中产生新的脂肪，从而导致脂肪异位堆积，激活核因子κB信号通路，释放肿瘤坏死因子α、白细胞介素1β（IL-1β）和IL-6等炎症因子，导致肥胖和胰岛素抵抗，最终引发系统性低度炎症。该综述回顾了不良饮食习惯导致系统性低度炎症的机制、瘢痕疙瘩与系统性低度炎症的临床研究与实验研究进展、饮食习惯与瘢痕疙瘩体质的关联性，提出了不良饮食习惯可能导致瘢痕疙瘩发生与发展的假说。
- 瘢痕疙瘩 /
- 饮食习惯 /
- 炎症 /
- 胃肠道微生物组 /
- 系统性低度炎症
Abstract: Long-term poor dietary habits can cause changes in the intestinal flora, resulting in the production of a large number of lipopolysaccharide, increase intestinal mucosal permeability, and activate the entrance of a large number of inflammatory factors into the portal vein. In addition, a high carbohydrate diet can increase liver metabolic burden, increase mitochondrial oxidative phosphorylation, leading to oxidative stress, generate new fat during adenosine triphosphate synthesis, and thus resulting in ectopic fat accumulation, which further activate nuclear factor-κB signaling pathway and release inflam- matory factors such as tumor necrosis factor-α, interleukin-1β (IL-1β), IL-6, and so on. This leads to obesity and insulin resis- tance, ultimately triggering systemic low-grade inflammation. This article reviews the mechanism of poor dietary habits leading to systemic low-grade inflammation, the clinical and experimental research progress of keloids and systemic low-grade inflammation, the association between dietary habits and keloid constitution, and puts forward the hypothesis that poor dietary habits may lead to the occurrence and development of keloids.
- Keloid /
- Food habits /
- Inflammation /
- Gastrointestinal microbiome /
- Systemic low-grade inflammation
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1 高碳水化合物与高脂饮食习惯导致系统性低度炎症的机制

注：IL为白细胞介素，MCP-1为单核细胞趋化蛋白1，TNF-α为肿瘤坏死因子α，JNK为c-Jun氨基端激酶，ATP为腺苷三磷酸，LPS为内毒素/脂多糖，TLR为Toll样受体，NOD2为核苷酸结合寡聚化结构域2

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