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摘要: 近20年来，细胞生物学技术的发展推动了瘢痕疙瘩的相关研究。瘢痕疙瘩成纤维细胞（KFb）是瘢痕疙瘩中的主要效应细胞，与瘢痕疙瘩的发生发展密切相关。KFb在生物学特性、基因表达等方面与正常成纤维细胞有明显差异。该文从多个角度对KFb的特性进行了综述，详细描述了其生物学特性如显微结构、代谢特点、增殖性质等情况，并介绍了KFb的异质性与基因组学等方面的主要特征。对KFb研究的不断深入将有助于阐明瘢痕疙瘩的发病机制并为瘢痕疙瘩的防治提供宝贵策略。Abstract: In re-cent 20 years, the development of cell biology technology has promoted the research of keloid. Keloid fibroblasts (KFbs) are the main effector cells in keloid, which are closely related to the occurrence and development of keloid. It is significantly different in terms of biological characteristics and gene expression between KFbs and normal fibroblasts. This articles reviews the characteristics of KFbs from multiple perspectives, describing its biological character- istics in details including microstructures, metabolic character- istics, and proliferation properties, and introducing the main characteristics of heterogeneity and genomics of KFbs. The further research on KFbs will help to elucidate the pathogenesis of keloids and provide valuable strategies for the prevention and treatment of keloids.
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Key words:
- Keloid /
- Fibroblasts /
- Genes /
- Biological characteristics /
- Signaling pathway
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参考文献
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表1 13篇文献的瘢痕疙瘩成纤维细胞微阵列芯片研究结果
第1作者 年份 类别 微阵列芯片分析 Hsu［5］ 2018 基因 345种基因↑，86种基因↓ Inui［38］ 2011 基因 374种基因↑，758种基因↓ Wong［39］ 2014 基因 250种基因差异表达 Satish［40］ 2006 基因 43种基因↑，5种基因↓ Seifert［31］ 2008 基因 97种基因↑，26种基因↓ Hahn［41］ 2013 基因 12种基因↑，13种基因↓ Li［42］ 2016 基因 196种基因↑，462种基因↓ 郭晓瑞［43］ 2011 miR 1种miR↑，11种miR↓ Wu［35］ 2014 miR 3种miR↑，14种miR↓ Wu［44］ 2019 miR 63种miR↑，76种miR↓ Yan［45］ 2020 miR 14种miR↑，15种miR↓ Liang［46］ 2015 lncRNA 1 731种lncRNA↑，782种lncRNA↓ Guo［47］ 2016 lncRNA 1 290种lncRNA↑，778种lncRNA↓ 注：miR为微小RNA, lncRNA为长链非编码RNA；↑表示上调，↓表示下调 
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《中华烧伤与创面修复杂志》第六届编辑委员会通讯编委名单按姓氏拼音排序
贲道锋 卞徽宁 曹永倩 晁生武 陈辉 陈婧 陈朗 陈铭锐 陈鹏 陈晓东 陈忠勇 程君涛 迟云飞 储国平 党永明 邓呈亮 狄海萍 丁国兵 丁若虹 董茂龙 段红杰 段鹏 樊东力 房贺 冯光 付忠华 郭毅斌 韩兆峰 侯春胜 胡德林 胡炯宇 胡骁骅 胡晓燕 黄红军 纪世召 江华 姜丽萍 姜玉峰 雷娜 黎宁 李东杰 李峰 李靖 李晓东 李晓鲁 梁钢 梁鹏飞 林才 林国安 林源 刘德伍 刘健 刘军 刘淑华 龙奕 卢长虹 鲁峰 吕开阳 吕强 马思远 牛轶雯 欧阳军 乔亮 覃凤均 邱学文 曲滨 任超 沈江涌 石继红 宋慧锋 苏海涛 苏永涛 孙勇 孙瑜 谭江琳 唐修俊 滕苗 田社民 涂家金 汪虹 汪洋 王爱萍 王德怀 王洪涛 王会军 王良喜 王爽 王献珍 王志永 温冰 邬佳敏 吴红 吴继炎 吴巍巍 吴祖煌 向飞 向军 谢举临 谢松涛 辛海明 许喜生 许学文 薛斌 杨建民 杨敏烈 杨薛康 姚明 姚兴伟 叶祥柏 易成刚 易南 于东宁 岳丽青 翟红军 詹日兴 张博 张东霞 张红艳 张菊芳 张玲娟 张庆红 张彦琦 张寅 张元海 张志 赵全 赵冉 赵雄 郑德义 郑东风 郑军 周国富 周俊峄 周琴 周万芳 朱峰 朱宇刚 祝筱梅 邹立津 邹晓防
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