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多功能水凝胶敷料治疗糖尿病致慢性创面的研究进展

曹望北 高长有

曹望北, 高长有. 多功能水凝胶敷料治疗糖尿病致慢性创面的研究进展[J]. 中华烧伤杂志, 2021, 37(11): 1090-1098. DOI: 10.3760/cma.j.cn501120-20210715-00249.
引用本文: 曹望北, 高长有. 多功能水凝胶敷料治疗糖尿病致慢性创面的研究进展[J]. 中华烧伤杂志, 2021, 37(11): 1090-1098. DOI: 10.3760/cma.j.cn501120-20210715-00249.
Cao WB,Gao CY.Research advances on multifunctional hydrogel dressings for treatment of diabetic chronic wounds[J].Chin J Burns,2021,37(11):1090-1098.DOI: 10.3760/cma.j.cn501120-20210715-00249.
Citation: Cao WB,Gao CY.Research advances on multifunctional hydrogel dressings for treatment of diabetic chronic wounds[J].Chin J Burns,2021,37(11):1090-1098.DOI: 10.3760/cma.j.cn501120-20210715-00249.

多功能水凝胶敷料治疗糖尿病致慢性创面的研究进展

doi: 10.3760/cma.j.cn501120-20210715-00249
基金项目: 

国家自然科学基金面上项目 51873188

浙江省自然科学基金 LD21E030001

详细信息
    通讯作者:

    高长有,Email:cygao@zju.edu.cn

Research advances on multifunctional hydrogel dressings for treatment of diabetic chronic wounds

Funds: 

General Program of National Natural Science Foundation of China 51873188

Natural Science Foundation of Zhejiang Province of China LD21E030001

More Information
    Corresponding author: Gao Changyou, Email: cygao@zju.edu.cn
  • 摘要:

    糖尿病会导致多种并发症如慢性创面(糖尿病足),是导致糖尿病患者死亡的重要原因之一。高血糖、高氧化应激水平、高炎症水平以及易感染等不利因素使糖尿病致慢性创面难以愈合,甚至进一步恶化。水凝胶材料由于具有含水量高、生物相容性好和理化性能可调控等优点,已成为当前创面敷料研究中的热点材料。相较于纱布等传统敷料,水凝胶敷料可为创面提供有利于愈合的湿润环境。通过负载活性物质和改变水凝胶组成及结构,水凝胶敷料可被赋予优异的组织黏附、抗菌、抗氧化以及调控炎症因子表达等功能,因此其在创面敷料应用领域中具有广阔的前景。本文基于糖尿病致慢性创面微环境和水凝胶材料的特点,总结了近年来用于治疗糖尿病致慢性创面的新型多功能水凝胶敷料的研究进展,同时探讨了当前水凝胶敷料的不足并提出展望。

     

  • 表1  当前临床所使用的创面敷料简介

    种类组成特点适应证
    凡士林油纱纤维素和凡士林廉价、干燥、需多次换药,易造成二次伤害广泛使用,但在复杂创面治疗时需配合其他操作或药物
    水凝胶敷料三维亲水聚合物网络渗出液吸收性强、优异的保湿性能(有利于清理坏死组织)、透明材质(可直接观察创面)、可负载活性分子、方便去除及换药干燥至中等量渗出液的非感染创面
    水胶体敷料水凝胶与合成橡胶以及黏性聚合物复合而成渗出液吸收性强、优异的保湿性能(有利于清理坏死组织)、皮肤黏合性良好,可用于关节处中等量渗出液的非感染创面
    藻酸盐类敷料褐藻内提取的多糖渗出液吸收性优异(吸收后成水凝胶态)、止血中等量至大量渗出液的感染或非感染创面
    海绵(泡沫)敷料硅胶或聚氨酯半透过性(可阻隔细菌)、保温保湿中等量至大量渗出液的非感染创面
    薄膜敷料胶黏剂和多孔透明聚氨酯薄膜透气性好、隔绝水和细菌渗出液较少的表面浅层非感染创面、上皮化创面
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