RNA N<sup>6</sup>-甲基腺嘌呤修饰在创面修复相关病理生理进程中的作用研究进展

刘笑笑; 刘德伍

doi:10.3760/cma.j.cn501120-20210804-00267

RNA N⁶-甲基腺嘌呤修饰在创面修复相关病理生理进程中的作用研究进展

doi: 10.3760/cma.j.cn501120-20210804-00267

刘笑笑,
刘德伍^,

南昌大学第一附属医院烧伤整形与创面修复医学中心，南昌　　330006

基金项目:

国家自然科学基金地区科学基金项目 81860340, 82160378

详细信息

通讯作者:
刘德伍，Email：dewuliu@126.com

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- PDF下载量: 12
- 被引次数: 0
出版历程
- 收稿日期: 2021-08-04
- 网络出版日期: 2022-10-24

Research advances on the effects of RNA N⁶-methyladenosine modification in the relevant pathophysiological processes of wound repair

Liu Xiaoxiao,
Liu Dewu^,

Medical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Funds:

Regional Science Fund Project of National Natural Science Foundation of China 81860340, 82160378

More Information

Corresponding author: Liu Dewu, Email: dewuliu@126.com

摘要

摘要: N⁶-甲基腺嘌呤（m⁶A）作为一种转录后修饰广泛存在于真核生物中，该种修饰受到甲基转移酶和去甲基化酶的动态可逆性调控，并通过m⁶A结合蛋白参与调节生物学效应。近来研究表明，m⁶A可参与胚胎皮肤形态发生、创面修复以及炎症反应、血管生成和纤维化等病理生理过程。该文概述了m⁶A及其相关蛋白在创面修复相关病理生理进程中的作用，以期为创面修复的治疗策略提供新的理论依据。
- RNA加工，转录后 /
- 病理学 /
- 新生血管化，生理性 /
- 纤维化 /
- N⁶-甲基腺嘌呤 /
- 调控蛋白 /
- 创面修复
Abstract: N⁶-methyladenosine (m⁶A) exists widely in eukaryotes as a post-transcriptional modification. This modification is dynamically and reversibly regulated by methyltransferases and demethylases, and is involved in regulating biological effects through m⁶A binding proteins. Recent studies have elucidated that m⁶A is involved in embryonic skin morphogenesis, wound repair, and pathophysiological processes such as inflammatory response, angiogenesis, and fibrosis. This review summarizes the role of m⁶A and its related proteins in the related pathophysiological processes of wound repair, so as to provide a new theoretical basis for the treatment strategy of wound repair.
- RNA processing, post-transcriptional /
- Pathology /
- Neovascularization, physiologic /
- Fibrosis /
- N⁶-methyladenosine /
- Regulatory proteins /
- Wound repair
所有作者均声明不存在利益冲突

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1 m⁶A介导的RNA调控机制示意图

注：METTL为甲基转移酶样，WTAP为Wilms肿瘤1结合蛋白，KIAAI429为Vir样N⁶-甲基腺嘌呤（m⁶A）相关甲基转移酶，ZC3H13为具有CCCH结构锌指蛋白13，RBM15/15B为RNA结合基序蛋白15/15B，ALKBH5为烷基化蛋白AlkB同源物5，FTO为肥胖相关蛋白，HNRNP为核不均一核糖核酸蛋白，YTHDC1为含有YTH结构域1，YTHDF为YTH结构域家族，IGF2BP为胰岛素样生长因子2 mRNA结合蛋白

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