应用功能材料促进皮肤创面修复

罗高兴; 刘梦龙

doi:10.3760/cma.j.cn501120-20210930-00340

应用功能材料促进皮肤创面修复

doi: 10.3760/cma.j.cn501120-20210930-00340

罗高兴^,,
刘梦龙

陆军军医大学（第三军医大学）第一附属医院全军烧伤研究所，创伤、烧伤与复合伤国家重点实验室，重庆市疾病蛋白质组学重点实验室　　400038

基金项目:

国家自然科学基金重点国际合作项目 81920108022

国家自然科学基金重点项目 81630055

详细信息

通讯作者:
罗高兴，Email：logxw@yahoo.com

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出版历程
- 收稿日期: 2021-09-30

Application of functional materials to promote cutaneous wound healing

Luo Gaoxing^,,
Liu Menglong

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China

Funds:

Key International Cooperation Program of National Natural Science Foundation of China 81920108022

Key Program of National Natural Science Foundation of China 81630055

More Information

Corresponding author: Luo Gaoxing, Email: logxw@yahoo.com

摘要

摘要: 皮肤创面是临床常见病症之一。功能材料通过结构调节和性能整合，可以针对性地对创面进行保护并促进创面愈合，目前已在创面修复领域得到广泛应用，是临床创面治疗的重要工具之一。本文分别就止血类、抗菌类、抗炎类、促血管化类及调控创面微环境类功能材料在创面修复中的应用做一总结。
- 皮肤 /
- 伤口愈合 /
- 功能材料 /
- 创面微环境
Abstract: Cutaneous wound is one of the common clinical diseases. Functional materials can provide targeted wound protection and promote wound healing through the structural adjustment and functional integration. Currently, functional materials have been widely used in the field of wound repair, becoming one of the important tools for clinical wound treatment. This paper summarizes the application of functional materials of following categories including hemostasis, antibacterial, anti-inflammation, vascularization, and regulation of wound microenvironment in wound repair.
- Skin /
- Wound healing /
- Functional materials /
- Wound microenvironment
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参考文献(37)

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脱细胞真皮基质（ADM）	重症监护病房（ICU）	动脉血氧分压（PaO₂）
丙氨酸转氨酶（ALT）	白细胞介素（IL）	磷酸盐缓冲液（PBS）
急性呼吸窘迫综合征（ARDS）	角质形成细胞（KC）	反转录-聚合酶链反应（RT-PCR）
天冬氨酸转氨酶（AST）	半数致死烧伤面积（LA50）	全身炎症反应综合征（SIRS）
集落形成单位（CFU）	内毒素/脂多糖（LPS）	超氧化物歧化酶（SOD）
细胞外基质（ECM）	丝裂原活化蛋白激酶（MAPK）	动脉血氧饱和度（SaO₂）
表皮生长因子（EGF）	最低抑菌浓度（MIC）	体表总面积（TBSA）
酶联免疫吸附测定（ELISA）	多器官功能障碍综合征（MODS）	转化生长因子（TGF）
成纤维细胞（Fb）	多器官功能衰竭（MOF）	辅助性T淋巴细胞（Th）
成纤维细胞生长因子（FGF）	一氧化氮合酶（NOS）	肿瘤坏死因子（TNF）
3-磷酸甘油醛脱氢酶（GAPDH）	负压伤口疗法（NPWT）	血管内皮生长因子（VEGF）
苏木精-伊红（HE）	动脉血二氧化碳分压（PaCO₂）	负压封闭引流（VSD）