留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

改善脓毒症患者长期预后的康复治疗对策

姚咏明 张卉

姚咏明, 张卉. 改善脓毒症患者长期预后的康复治疗对策[J]. 中华烧伤与创面修复杂志, 2022, 38(3): 201-206. DOI: 10.3760/cma.j.cn501120-20211004-00344.
引用本文: 姚咏明, 张卉. 改善脓毒症患者长期预后的康复治疗对策[J]. 中华烧伤与创面修复杂志, 2022, 38(3): 201-206. DOI: 10.3760/cma.j.cn501120-20211004-00344.
Yao YM,Zhang H.Rehabilitation strategy for the improvement of long-term outcomes of patients after sepsis[J].Chin J Burns Wounds,2022,38(3):201-206.DOI: 10.3760/cma.j.cn501120-20211004-00344.
Citation: Yao YM,Zhang H.Rehabilitation strategy for the improvement of long-term outcomes of patients after sepsis[J].Chin J Burns Wounds,2022,38(3):201-206.DOI: 10.3760/cma.j.cn501120-20211004-00344.

改善脓毒症患者长期预后的康复治疗对策

doi: 10.3760/cma.j.cn501120-20211004-00344
基金项目: 

国家自然科学基金重点项目 82130062, 81730057

国家自然科学基金面上项目 81871580

军事医学创新工程重点项目 18CXZ026

详细信息
    通讯作者:

    姚咏明,Email:c_ff@sina.com

Rehabilitation strategy for the improvement of long-term outcomes of patients after sepsis

Funds: 

Key Program of National Natural Science Foundation of China 82130062, 81730057

General Program of National Natural Science Foundation of China 81871580

Key Project of Innovation Engineering in Military Medicine 18CXZ026

More Information
  • 摘要: 脓毒症存活患者出院后仍然面临较高的二次感染和死亡风险,并且长期遗留认知功能、精神和肢体运动功能障碍,严重影响患者的长期预后和生活质量。本文浅析脓毒症预后不良的主要因素,进而从心理干预、早期活动、营养支持和免疫调理等方面阐述有利于改善脓毒症患者长期预后的康复治疗对策。

     

  • [1] RuddKE, JohnsonSC, AgesaKM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study[J]. Lancet, 2020, 395(10219): 200-211. DOI: 10.1016/S0140-6736(19)32989-7.
    [2] IwashynaTJ, ElyEW, SmithDM, et al. Long-term cognitive impairment and functional disability among survivors of severe sepsis[J]. JAMA, 2010, 304(16): 1787-1794. DOI: 10.1001/jama.2010.1553.
    [3] MostelZ, PerlA, MarckM, et al. Post-sepsis syndrome - an evolving entity that afflicts survivors of sepsis[J].Mol Med,2019,26(1):6.DOI: 10.1186/s10020-019-0132-z.
    [4] YendeS, Linde-ZwirbleW, MayrF, et al. Risk of cardiovascular events in survivors of severe sepsis[J]. Am J Respir Crit Care Med, 2014, 189(9): 1065-1074. DOI: 10.1164/rccm.201307-1321OC.
    [5] PrescottHC, CostaDK. Improving long-term outcomes after sepsis[J]. Crit Care Clin, 2018, 34(1): 175-188. DOI: 10.1016/j.ccc.2017.08.013.
    [6] 张卉,冯永文,姚咏明.深刻理解烧创伤脓毒症发病机制的网络效应[J].中华医学杂志,2020,100(12):881-885.DOI: 10.3760/cma.j.cn112137-20191129-02603.
    [7] AnnaneD, SharsharT. Cognitive decline after sepsis[J]. Lancet Respir Med, 2015, 3(1): 61-69. DOI: 10.1016/S2213-2600(14)70246-2.
    [8] SemmlerA, FrischC, DebeirT, et al. Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model[J].Exp Neurol,2007,204(2):733-740.DOI: 10.1016/j.expneurol.2007.01.003.
    [9] 任超, 李秀花, 许碧磊, 等.中枢拮抗高迁移率族蛋白B1对脓毒症脑损伤的影响[J].中华急诊医学杂志, 2016, 25(4): 433-438. DOI: 10.3760/cma.j.issn.1671-0282.2016.04.008.
    [10] ChavanSS, HuertaPT, RobbiatiS, et al. HMGB1 mediates cognitive impairment in sepsis survivors[J]. Mol Med, 2012, 18(1): 930-937. DOI: 10.2119/molmed.2012.00195.
    [11] NikayinS, RabieeA, HashemMD, et al. Anxiety symptoms in survivors of critical illness: a systematic review and meta- analysis[J].Gen Hosp Psychiatry,2016,43:23-29.DOI: 10.1016/j.genhosppsych.2016.08.005.
    [12] RabieeA, NikayinS, HashemMD, et al. Depressive symptoms after critical illness: a systematic review and meta-analysis[J]. Crit Care Med, 2016, 44(9): 1744-1753. DOI: 10.1097/CCM.0000000000001811.
    [13] ParkerAM, SricharoenchaiT, RaparlaS, et al. Posttraumatic stress disorder in critical illness survivors: a metaanalysis[J]. Crit Care Med, 2015, 43(5): 1121-1129. DOI: 10.1097/CCM.0000000000000882.
    [14] StevensRD, MarshallSA, CornblathDR, et al. A framework for diagnosing and classifying intensive care unit-acquired weakness[J].Crit Care Med,2009,37(10 Suppl):S299-308.DOI: 10.1097/CCM.0b013e3181b6ef67.
    [15] GeenseWW, van den BoogaardM, PetersMAA, et al. Physical, mental, and cognitive health status of ICU survivors before ICU admission: a cohort study[J]. Crit Care Med, 2020, 48(9): 1271- 1279. DOI: 10.1097/CCM.0000000000004443.
    [16] 董宁, 姚咏明, 曹玉珏, 等. 严重烧伤患者人白细胞抗原DR定量表达的临床意义[J]. 中华外科杂志, 2007, 45(11): 766-769. DOI: 10.3760/j.issn:0529-5815.2007.11.016.
    [17] DrewryAM, SamraN, SkrupkyLP, et al. Persistent lymphopenia after diagnosis of sepsis predicts mortality[J].Shock,2014,42(5):383-391.DOI: 10.1097/SHK.0000000000000234.
    [18] AugerC, SamadiO, JeschkeMG. The biochemical alterations underlying post-burn hypermetabolism[J]. Biochim Biophys Acta Mol Basis Dis, 2017, 1863(10 Pt B):2633-2644.DOI: 10.1016/j.bbadis.2017.02.019.
    [19] 姚咏明,张卉,童亚林.深化对烧伤脓毒症诊断体系与治疗策略的认识[J].中华烧伤杂志,2021,37(5):404-409.DOI: 10.3760/cma.j.cn501120-20200703-00337.
    [20] 吴田田, 童亚林, 姚咏明. 烧伤创面脓毒症的防治对策[J]. 创伤外科杂志, 2017, 19(5): 396-400. DOI: 10.3969/j.issn.1009-4237.2017.05.020.
    [21] EisensteinTK.The role of opioid receptors in immune system function[J].Front Immunol,2019,10:2904.DOI: 10.3389/fimmu.2019.02904.
    [22] JonesC. Over 20 years of ICU diary research 1999-2020[J]. Intensive Crit Care Nurs, 2021, 64: 102961. DOI: 10.1016/j.iccn.2020.102961.
    [23] Garrouste-OrgeasM, FlahaultC, VinatierI, et al. Effect of an ICU diary on posttraumatic stress disorder symptoms among patients receiving mechanical ventilation: a randomized clinical trial[J]. JAMA, 2019, 322(3): 229-239. DOI: 10.1001/jama.2019.9058.
    [24] 郑天歌, 张青杰, 贾靖仪, 等. 新型抗焦虑药物研究进展[J]. 中国药理学通报, 2021, 37(9): 1188-1196. DOI: 10.3969/j.issn.1001-1978.2021.09.002.
    [25] MorrisPE, GoadA, ThompsonC, et al. Early intensive care unit mobility therapy in the treatment of acute respiratory failure[J]. Crit Care Med, 2008, 36(8): 2238-2243. DOI: 10.1097/CCM.0b013e318180b90e.
    [26] SchweickertWD, PohlmanMC, PohlmanAS, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial[J]. Lancet, 2009, 373(9678): 1874-1882. DOI: 10.1016/S0140-6736(09)60658-9.
    [27] VasilevskisEE, ElyEW, SperoffT, et al. Reducing iatrogenic risks: ICU-acquired delirium and weakness: crossing the quality chasm[J]. Chest, 2010, 138(5): 1224-1233. DOI: 10.1378/chest.10-0466.
    [28] Barnes-DalyMA, PhillipsG, ElyEW. Improving hospital survival and reducing brain dysfunction at seven California community hospitals: implementing PAD guidelines via the ABCDEF bundle in 6,064 patients[J]. Crit Care Med, 2017, 45(2): 171-178. DOI: 10.1097/CCM.0000000000002149.
    [29] KimT, HuhS, KimSY, et al. ICU rehabilitation is associated with reduced long-term mortality from sepsis in patients with low skeletal muscle mass: a case control study[J]. Ann Transl Med, 2019, 7(18): 430. DOI: 10.21037/atm.2019.08.117.
    [30] ZusmanO, TheillaM, CohenJ, et al. Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study[J]. Crit Care, 2016, 20(1): 367. DOI: 10.1186/s13054-016-1538-4.
    [31] WACKKoekkoek, van SettenCHC, OlthofLE, et al. Timing of protein intake and clinical outcomes of adult critically ill patients on prolonged mechanical ventilation: the protinvent retrospective study[J]. Clin Nutr, 2019, 38(2): 883-890. DOI: 10.1016/j.clnu.2018.02.012.
    [32] CruzatV, RogeroMM, KeaneKN, et al. Glutamine: metabolism and immune function, supplementation and clinical translation[J]. Nutrients, 2018, 10(11): 1564. DOI: 10.3390/nu10111564.
    [33] StehleP, EllgerB, KojicD, et al. Glutamine dipeptide- supplemented parenteral nutrition improves the clinical outcomes of critically ill patients: a systematic evaluation of randomised controlled trials[J].Clin Nutr ESPEN,2017,17:75-85.DOI: 10.1016/j.clnesp.2016.09.007.
    [34] SingerP, BlaserAR, BergerMM, et al. ESPEN guideline on clinical nutrition in the intensive care unit[J]. Clin Nutr, 2019, 38(1): 48-79. DOI: 10.1016/j.clnu.2018.08.037.
    [35] 姚咏明, 张卉, 李春盛. 脓毒症治疗新策略: 免疫调理研究新认识[J]. 医学与哲学, 2017, 38(2B): 28-31,42. DOI: 10.12014/j.issn.1002-0772.2017.02b.04.
    [36] 脓毒症免疫调理治疗临床研究协作组.乌司他丁、α1胸腺肽联合治疗严重脓毒症——一种新的免疫调理治疗方法的临床研究[J].中华医学杂志,2007,87(7):451-457.DOI: 10.3760/j:issn:0376-2491.2007.07.005.
  • 加载中
计量
  • 文章访问数:  2257
  • HTML全文浏览量:  60
  • PDF下载量:  62
  • 被引次数: 0
出版历程
  • 收稿日期:  2021-10-04

目录

    /

    返回文章
    返回