药物干预增生性瘢痕的研究进展

史亮亮; 刘名倬; 江政英; 虞小亭; 李嘉琪; 郭光华

doi:10.3760/cma.j.cn501120-20211118-00388

药物干预增生性瘢痕的研究进展

doi: 10.3760/cma.j.cn501120-20211118-00388

南昌大学第一附属医院烧伤整形与创面修复医学中心，南昌　　330006

基金项目:

国家自然科学基金地区科学基金项目 82160376, 81960352

江西省科学技术厅重点研发计划项目 20171ACG70004

江西省青年科学基金资助项目 20192BAB215029

详细信息

通讯作者:
郭光华，Email：guogh2000@hotmail.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-11-18

Research advances on pharmacological interventions for hypertrophic scar

Medical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Funds:

Regional Science Fund Project of National Natural Science Foundation of China 82160376, 81960352

Key Research and Development Plan of Science and Technology Department of Jiangxi Province of China 20171ACG70004

Youth Science Foundation of Jiangxi Province of China 20192BAB215029

More Information

Corresponding author: Guo Guanghua, Email: guogh2000@hotmail.com

摘要

摘要: 增生性瘢痕是皮肤深层损伤后出现的纤维异常增生性疾病，不但影响美观与功能，还会对患者心理产生不良影响。然而增生性瘢痕的发生机制尚未被完全阐明，其临床治疗复杂且复发率高，尚无确切的根治方法。基于分子靶点的干预，将可能是未来预防和治疗增生性瘢痕的方向。该文结合国内外相关基础研究与临床研究进展，围绕一般药物、细胞因子、免疫调节剂、中药提取物、外泌体、纳米材料等药物靶向干预增生性瘢痕的具体作用和机制进行综述。
- 瘢痕 /
- 药物疗法 /
- 二甲双胍 /
- 肉毒杆菌毒素类，A型 /
- 外泌体
Abstract: Hypertrophic scar is an abnormal fibrous proliferative disease that occurs after deep cutaneous injury, which not only affects aesthetics and function but also has negative psychological effects on the patients. However, the mechanism of hypertrophic scar formation has not been fully elucidated, and its clinical treatment is complex with a high rate of recurrence and no radicle cure. Intervention based on molecular targets will likely be the future direction for the prevention and treatment of hypertrophic scar. In this article, we review the specific roles and mechanisms of drug-targeted interventions in hypertrophic scar formation, including general drugs, cytokines, immunomodulators, herbal extracts, exosomes, and nanomaterials, in the context of advances in both basic and clinical research at home and abroad.
- Cicatrix /
- Drug therapy /
- Metformin /
- Botulinum toxins, type A /
- Exosomes
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