从第一个用于创烧伤治疗的基因工程国家一类新药研发与转化应用看创烧伤治疗“中国方案”的创立

付小兵; 李校堃

doi:10.3760/cma.j.cn501120-20211125-00397

从第一个用于创烧伤治疗的基因工程国家一类新药研发与转化应用看创烧伤治疗“中国方案”的创立

doi: 10.3760/cma.j.cn501120-20211125-00397

付小兵^{1, 2, ,},
李校堃³

1.
解放军总医院医学创新研究部创伤修复与组织再生研究中心，北京　　100853
2.
解放军总医院第四医学中心全军创伤修复与组织再生重点实验室，北京　　100048
3.
温州医科大学药学院，温州　　325035

详细信息

通讯作者:
付小兵，Email：fuxiaobing@vip.sina.com

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出版历程
- 收稿日期: 2021-11-25

Establishment of "Chinese way" for trauma and burn management based on the engineered growth factors research and application

Fu Xiaobing^{1, 2
, ,},
Li Xiaokun³

1.
Research Center for Wound Repair and Tissue Regeneration, Medical Innovation Research Department, the PLA General Hospital, Beijing 100853, China
2.
The Key Laboratory of PLA Wound Repair and Tissue Regeneration, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China
3.
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China

More Information

Corresponding author: Fu Xiaobing,Email:fuxiaobing@vip.sina.com

摘要

摘要: 创新与转化应用是近年来国内科学界反复讨论的重要话题。本文系统回顾生长因子研发和在我国创烧伤治疗中的应用过程及基于具有中国特色的创面治疗学科体系建设过程中形成创烧伤治疗“中国方案”的感悟和体会。希望这些弥足珍贵的历程能够对同行，特别是对青年一代具有一定的借鉴和启示作用。
- 创伤和损伤 /
- 烧伤 /
- 基因工程 /
- 生长因子
Abstract: Innovation and translation application are important topics that have been discussed repeatedly in national community of science and technology in recent years. We do a systemic review about the research and development history of growth factors, their application in trauma and burn management in China, and the conception and experience about the establishment of "Chinese way" for trauma and burn management in the process of constructing a disciplinary system for wound treatment with Chinese characteristics. It is our hope that these precious experiences will provide references and inspiration to our peers, especially the young generation in their research.
- Wounds and injuries /
- Burns /
- Gene engineering /
- Growth factors
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参考文献(11)

[1]	付小兵.生长因子与创伤修复[M].北京:人民军医出版社,1991.
[2]	FuX, SunX, LiX, et al.Dedifferentiation of epidermal cells to stem cells in vivo[J]. Lancet, 2001,358(9287):1067-1068. DOI: 10.1016/S0140-6736(01)06202-X.
[3]	XiaoJ,LinZ,QinH,et al.Growth factor regulatory system: a new system for not truly recognized organisms[J].Sci China Life Sci,2020,63(3):443-446.DOI: 10.1007/s11427-019-1590-x.
[4]	FuX,ShenZ,ChenY,et al.Recombinant bovine basic fibroblast growth factor accelerates wound healing in patients with burns, donor sites and chronic dermal ulcers[J].Chin Med J (Engl),2000,113(4):367-371.
[5]	FuX,ShenZ,ChenY,et al.Randomised placebo-controlled trial of use of topical recombinant bovine basic fibroblast growth factor for second-degree burns[J].Lancet,1998,352(9141):1661-1664.DOI: 10.1016/S0140-6736(98)01260-4.
[6]	LindbladWJ. Bridging traditions[J]. Wound Repair Regen, 2001, 9(1):1. DOI: 10.1046/j.1524-475x.2001.00001.x.
[7]	国家卫生健康委办公厅国家卫生健康委办公厅关于加强体表慢性难愈合创面( 溃疡) 诊疗管理工作的通知 2019-11-29 2021-11-25 http://www.nhc.gov.cn/yzygj/s7659/201912/602716f0471944b8b63b0adabe4546df.shtml 国家卫生健康委办公厅.国家卫生健康委办公厅关于加强体表慢性难愈合创面( 溃疡) 诊疗管理工作的通知[EB/OL].(2019-11-29)[2021-11-25].http://www.nhc.gov.cn/yzygj/s7659/201912/602716f0471944b8b63b0adabe4546df.shtml.
[8]	ManiR. Looking east[J].Int J Low Extrem Wounds,2012,11(3):146.DOI: 10.1177/1534734612456921.
[9]	付小兵.治疗创烧伤国家一类新药基因工程生长因子的研发与转化应用:主要历程与思索[J].中华创伤杂志,2018,34(12):1057-1061. DOI: 10.3760/cma.j.issn.1001-8050.2018.12.001.
[10]	KørblingM, EstrovZ. Adult stem cells for tissue repair - a new therapeutic concept?[J]. N Engl J Med, 2003,349(6):570-582. DOI: 10.1056/NEJMra022361.
[11]	BeardsleyTM. Back to the future[J]. BioScience, 2007, 57(8): 643.