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脂肪干细胞外泌体在皮肤瘢痕形成中的作用研究进展

王刘欣 李云鹏 吴思默 张浚睿 孔亮 陆斌 刘富伟 李治冶

王刘欣, 李云鹏, 吴思默, 等. 脂肪干细胞外泌体在皮肤瘢痕形成中的作用研究进展[J]. 中华烧伤与创面修复杂志, 2023, 39(3): 295-300. DOI: 10.3760/cma.j.cn501225-20220308-00057.
引用本文: 王刘欣, 李云鹏, 吴思默, 等. 脂肪干细胞外泌体在皮肤瘢痕形成中的作用研究进展[J]. 中华烧伤与创面修复杂志, 2023, 39(3): 295-300. DOI: 10.3760/cma.j.cn501225-20220308-00057.
Wang LX,Li YP,Wu SM,et al.Research progress on the role of adipose-derived stem cell exosomes in skin scar formation[J].Chin J Burns Wounds,2023,39(3):295-300.DOI: 10.3760/cma.j.cn501225-20220308-00057.
Citation: Wang LX,Li YP,Wu SM,et al.Research progress on the role of adipose-derived stem cell exosomes in skin scar formation[J].Chin J Burns Wounds,2023,39(3):295-300.DOI: 10.3760/cma.j.cn501225-20220308-00057.

脂肪干细胞外泌体在皮肤瘢痕形成中的作用研究进展

doi: 10.3760/cma.j.cn501225-20220308-00057
基金项目: 

国家自然科学基金青年科学基金项目 81801969

国家自然科学基金面上项目 81970988

军事口腔医学国家重点实验室2019年度自主研究课题A类项目 2019ZA08

详细信息
    通讯作者:

    李治冶,Email:verylzy@163.com

Research progress on the role of adipose-derived stem cell exosomes in skin scar formation

Funds: 

Youth Science Foundation Project of National Natural Science Foundation of China 81801969

General Program of National Natural Science Foundation of China 81970988

Independent Research Project (Class A) of State Key Laboratory of Military Stomatology in 2019 2019ZA08

More Information
  • 摘要: 脂肪干细胞外泌体是脂肪干细胞分泌的亚细胞结构,是一种可以运输多种细胞成分并通过旁分泌作用于靶细胞的纳米级膜囊泡,在细胞间的物质交换及信息交流中起着重要作用。瘢痕愈合是皮肤组织损伤后最常见的愈合方式,病理性瘢痕不仅会造成运动功能障碍,还会导致畸形,影响患者外观,给患者带来生活及精神上的压力。近年来,许多研究表明脂肪干细胞外泌体内含有多种生物活性分子,这些分子通过影响成纤维细胞的增殖与迁移及细胞外基质的成分,从而对减少瘢痕形成及无瘢痕创面愈合起重要作用。该文主要对近年来关于脂肪干细胞外泌体在瘢痕形成中的作用及其机制的文献进行综述,并对未来脂肪干细胞外泌体在瘢痕治疗中的应用发展进行展望。

     

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出版历程
  • 收稿日期:  2022-03-08
  • 网络出版日期:  2023-03-23

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