坏疽性脓皮病的治疗现状及最新进展

李杨; 王园园; 邢可; 李珊山

doi:10.3760/cma.j.cn501225-20220330-00108

坏疽性脓皮病的治疗现状及最新进展

doi: 10.3760/cma.j.cn501225-20220330-00108

吉林大学第一医院皮肤科，长春　　130021

详细信息

通讯作者:
李珊山，Email：lishans@jlu.edu.cn

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出版历程
- 收稿日期: 2022-03-30

Current situation and the latest progress in the treatment of pyoderma gangrenosum

Department of Dermatology, the First Hospital of Jilin University, Changchun 130021, China

More Information

Corresponding author: Li Shanshan, Email: lishans@jlu.edu.cn

摘要

摘要: 坏疽性脓皮病（PG）是一种少见的慢性炎症性非感染性皮肤病，现国内外没有明确的针对该病的治疗指南。临床上针对PG有多种治疗方法，包括局部治疗以及系统应用糖皮质激素、免疫抑制剂、静脉注射Ig及生物制剂等，其中，糖皮质激素为临床上常用的一线药物，免疫抑制剂可单独使用或联合糖皮质激素使用。近些年越来越多的证据表明生物制剂是治疗PG的新趋势，主要制剂包括肿瘤坏死因子α抑制剂、白细胞介素1（IL-1）抑制剂、IL-12/23抑制剂、IL-17抑制剂、利妥昔单抗及小分子抑制剂。该文针对PG的治疗现状及最新进展进行归纳总结，希望能为临床医师治疗PG提供思路。
- 坏疽性脓皮病 /
- 临床方案 /
- 糖皮质激素类 /
- 免疫抑制剂 /
- 生物制剂
Abstract: Pyoderma gangrenosum (PG) is a rare chronic inflammatory non-infectious skin dermatosis, and there is no clear treatment guideline for this disease at home and abroad. There are a variety of clinical treatment methods for PG, including local therapy and systemic application of glucocorticoids, immunosuppressants, intravenous immuno- globulin, and biologics. Glucocorticoids are the first-line drugs commonly used in clinical practice, and immunosuppressants can be used alone or in combination with glucocorticoids. In recent years, more and more evidence has shown that biologics are a new trend in the treatment of PG, mainly including tumor necrosis factor α inhibitors, interleukin-1 (IL-1) inhibitors, IL-12/23 inhibitors, IL-17 inhibitors, rituximab, and small molecular inhibitors. This article summarizes the current status and latest progress in the treatment of PG, hoping to provide clinicians with ideas for the treatment of PG.
- Pyoderma gangrenosum /
- Clinical protocols /
- Glucocorticoids /
- Immunosuppressive agents /
- Biologics
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