Research advances of stem cell-based tissue engineering repair materials in promoting the healing of chronic refractory wounds on the body surface
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摘要: 体表慢性难愈合创面的修复是一个复杂的医学问题,涉及创面愈合的各个阶段。近年来干细胞及组织工程为修复慢性难愈合创面带来了希望。干细胞具有良好的再生能力和旁分泌作用;多种组织工程策略有修复体表慢性难愈合创面的潜力,还可以提高干细胞的递送效率。该文对慢性难愈合创面的病理特征、用于修复慢性难愈合创面的干细胞、基于干细胞的组织工程创面修复策略等进行综述。Abstract: Repairing chronic refractory wounds on the body surface is a complex medical problem involving all stages of wound healing. In recent years, stem cells (SCs) and tissue engineering (TE) have brought hope for repairing chronic refractory wounds. SCs have excellent regenerative and paracrine effects; various TE strategies have the potential to repair chronic refractory wounds on the body surface and also improve the delivery efficiency of SCs. This article reviews the pathological characteristics of chronic refractory wounds, SCs used to repair chronic refractory wounds, and SC-based TE wound repair strategies.
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Key words:
- Stem cells /
- Tissue engineering /
- Regenerative medicine /
- Chronic wound /
- Wound repair
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