生长因子调控创面修复的进展与思考

肖健; 张凡

doi:10.3760/cma.j.cn501225-20220416-00139

生长因子调控创面修复的进展与思考

doi: 10.3760/cma.j.cn501225-20220416-00139

肖健^,,
张凡

温州医科大学附属第一医院创面修复科　温州医科大学创伤修复与再生医学中心　温州医科大学药学院，温州　　325035

基金项目:

国家自然科学基金优秀青年科学基金项目 81722028

温州市重大科技创新攻关项目 ZY2020023

详细信息

通讯作者:
肖健，Email：xfxj2000@126.com

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出版历程
- 收稿日期: 2022-04-16

Progress and thoughts on the regulation of wound repair by growth factors

Xiao Jian^,,
Zhang Fan

Department of Wound Repair, the First Affiliated Hospital of Wenzhou Medical University, Wound Repair and Regenerative Medicine Center, Wenzhou Medical University, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, China

Funds:

Excellent Young Program of National Natural Science Foundation of China 81722028

Wenzhou Science and Technology Innovation Project ZY2020023

More Information

Corresponding author: Xiao Jian, Email: xfxj2000@126.com

摘要

摘要: 生长因子在创面愈合中起重要调控作用，其主要通过激活相关信号通路加速创面愈合。中国科学家对生长因子的基础、临床研究至今已有30年历史，研发的生长因子系列药物被广泛应用于烧创伤及慢性难愈合溃疡的治疗。该文从免疫、神经、脂肪等多个角度阐述了生长因子对创面修复的前沿进展，并提出了该研究团队对生长因子调控创面修复的进一步思考。
- 伤口愈合 /
- 皮肤 /
- 生长因子 /
- 调控
Abstract: Growth factors play an important role in wound healing, and they mainly accelerate wound healing by activating the related signal pathways. Chinese scientists have been conducting basic and clinical researches on growth factors for 30 years, with a series of growth factor drugs being developed and widely used in the treatment of burns and trauma and chronic refractory ulcers. This paper expounds the frontier progress of growth factors on wound healing from the perspectives of immunity, nerve, fat, and so on, and puts forward the further thoughts of the research team on the regulation of wound healing by growth factors.
- Wound healing /
- Skin /
- Growth factor /
- Regulation
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参考文献(27)

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脱细胞真皮基质（ADM）	重症监护病房（ICU）	动脉血氧分压（PaO₂）
丙氨酸转氨酶（ALT）	白细胞介素（IL）	磷酸盐缓冲液（PBS）
急性呼吸窘迫综合征（ARDS）	角质形成细胞（KC）	反转录-聚合酶链反应（RT-PCR）
天冬氨酸转氨酶（AST）	半数致死烧伤面积（LA50）	全身炎症反应综合征（SIRS）
集落形成单位（CFU）	内毒素/脂多糖（LPS）	超氧化物歧化酶（SOD）
细胞外基质（ECM）	丝裂原活化蛋白激酶（MAPK）	动脉血氧饱和度（SaO₂）
表皮生长因子（EGF）	最低抑菌浓度（MIC）	体表总面积（TBSA）
酶联免疫吸附测定（ELISA）	多器官功能障碍综合征（MODS）	转化生长因子（TGF）
成纤维细胞（Fb）	多器官功能衰竭（MOF）	辅助性T淋巴细胞（Th）
成纤维细胞生长因子（FGF）	一氧化氮合酶（NOS）	肿瘤坏死因子（TNF）
3-磷酸甘油醛脱氢酶（GAPDH）	负压伤口疗法（NPWT）	血管内皮生长因子（VEGF）
苏木精-伊红（HE）	动脉血二氧化碳分压（PaCO₂）	负压封闭引流（VSD）