丝素蛋白生物材料在创面修复中的应用研究进展

丁召召; 吕强

doi:10.3760/cma.j.cn501225-20220602-00212

丝素蛋白生物材料在创面修复中的应用研究进展

doi: 10.3760/cma.j.cn501225-20220602-00212

丁召召,
吕强^,

苏州大学现代丝绸国家工程实验室与苏州纳米科技协同创新中心，苏州　　215123

基金项目:

国家重点研发计划 2016YFE0204400

详细信息

通讯作者:
吕强，Email：lvqiang78@suda.edu.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2022-06-02
- 网络出版日期: 2022-10-24

Research advances on the application of silk fibroin biomaterials in wound repair

Ding Zhaozhao,
Lyu Qiang^,

National Engineering Laboratory for Modern SilkCollaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China

Funds:

National Key Research and Development Program of China 2016YFE0204400

More Information

Corresponding author: Lyu Qiang, Email: lvqiang78@suda.edu.cn

摘要

摘要: 丝素蛋白是一种天然纤维蛋白，具有生物相容性好、降解性能和力学性能可调、宿主炎症反应小、成本低、易制备等特性，是创面修复的理想基质材料。丝素蛋白可单独使用，也可将其同其他材料复合，制备成支架、水凝胶、膜、功能贴片和微针等不同材料，满足不同创面修复需求，调控创面修复过程，在皮肤组织工程中的应用研究急剧增加。同其他天然材料相比，丝素蛋白通过改善不同时期的细胞增殖、迁移和分化行为来促进组织再生和创面修复，表现出不同维度的独特优势。综合近年来丝素蛋白创面修复材料研究的进展，该文重点阐述丝素蛋白及其复合材料在创面修复中的作用机制和应用前景。
- 丝素蛋白 /
- 皮肤 /
- 生物敷料 /
- 组织工程 /
- 创面修复
Abstract: Silk fibroin, a natural fibrin, is a suitable matrix biomaterial for wound repair due to its unique properties such as good biocompatibility, tunable biodegradation and mechanical properties, low host inflammatory response, low cost, ease of fabrication, etc. Silk fibroin can be used alone or in combination with other materials to construct various dressings including scaffolds, hydrogels, films, smart mats, and microneedles, which can meet the needs of different wound repair and regulate the wound repair process. Thus, the application research of silk fibroin in skin tissue engineering has increased dramatically. Compared with other natural materials, silk fibroin promotes tissue regeneration and wound repair by improving cell proliferation, migration, and differentiation behavior at different stages, showing unique advantages in different dimensions. Based on the development of silk fibroin wound repair materials in the recent years, this review focuses on the mechanism and application prospect of silk fibroin and its composite materials in wound repair.
- Silk /
- Skin /
- Biological dressings /
- Tissue engineering /
- Wound repair
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