环状RNA在糖尿病创面愈合中的作用机制研究进展

农与乐; 吕叶辉

doi:10.3760/cma.j.cn501225-20220727-00317

环状RNA在糖尿病创面愈合中的作用机制研究进展

doi: 10.3760/cma.j.cn501225-20220727-00317

农与乐¹,
吕叶辉^2, ,

1.
上海健康医学院创面防治研究所，上海　　201318
2.
上海健康医学院基础医学院，　上海　　201318

基金项目:

国家级大学生创新训练计划 202210262013

上海市青年科技英才扬帆计划 21YF1418800

详细信息

通讯作者:
吕叶辉，Email：lvyh_15@sumhs.edu.cn

计量
- 文章访问数: 197
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- PDF下载量: 27
- 被引次数: 0
出版历程
- 收稿日期: 2022-07-27

Research advances on the mechanism of circular RNA in diabetic wound healing

Nong Yule¹,
Lyu Yehui^{2
, ,}

1.
Institute of Wound Prevention and Treatment, Shanghai University of MedicineHealth Sciences, Shanghai 201318, China
2.
School of Basic Medical Sciences, Shanghai University of MedicineHealth Sciences, Shanghai 201318, China

Funds:

National Training Program for College Students′ Innovation 202210262013

Shanghai Sailing Program 21YF1418800

More Information

Corresponding author: Lyu Yehui, Email: lvyh_15@sumhs.edu.cn

摘要

摘要: 近年来，大量研究表明非编码RNA在创面愈合过程中发挥着重要作用。其中关于环状RNA（circRNA）作用机制的研究显示，circRNA与创面愈合相关的细胞，如内皮祖细胞、角质形成细胞的增殖密切相关，也参与了慢性创面愈合过程。该文在简述circRNA相关概念的基础上，聚焦circRNA在糖尿病创面愈合不同阶段中可能的调控作用机制，也归纳了circRNA在糖尿病末梢血管粥样硬化进程中的潜在作用，旨在深入探究circRNA在糖尿病创面愈合过程中的分子机制及临床意义，为进一步研究提供参考。
- 糖尿病 /
- 伤口愈合 /
- 环状RNA /
- 作用机制
Abstract: In recent years, a large number of studies have shown that non-coding RNAs play an important role in wound healing process. Among them, studies on the mechanism of circular RNA (circRNA) have shown that circRNA is closely related to the proliferation of cells related to wound healing, such as endothelial progenitor cells and keratinocytes, and circRNA is also involved in the chronic wound healing process. Based on the introduction of the related concept of circRNA, this paper focuses on the possible regulatory mechanism of circRNA in different stages of diabetic wound healing and summarizes the potential role of circRNA in the process of diabetic peripheral vascular atherosclerosis, aiming to explore the in-depth molecular mechanism and clinical significance of circRNA in diabetic wound healing process, and provide reference for further research.
- Diabetes mellitus /
- Wound healing /
- Circular RNA /
- Mechanism of action
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参考文献(36)

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