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摘要: 近年来,大量研究表明非编码RNA在创面愈合过程中发挥着重要作用。其中关于环状RNA(circRNA)作用机制的研究显示,circRNA与创面愈合相关的细胞,如内皮祖细胞、角质形成细胞的增殖密切相关,也参与了慢性创面愈合过程。该文在简述circRNA相关概念的基础上,聚焦circRNA在糖尿病创面愈合不同阶段中可能的调控作用机制,也归纳了circRNA在糖尿病末梢血管粥样硬化进程中的潜在作用,旨在深入探究circRNA在糖尿病创面愈合过程中的分子机制及临床意义,为进一步研究提供参考。Abstract: In recent years, a large number of studies have shown that non-coding RNAs play an important role in wound healing process. Among them, studies on the mechanism of circular RNA (circRNA) have shown that circRNA is closely related to the proliferation of cells related to wound healing, such as endothelial progenitor cells and keratinocytes, and circRNA is also involved in the chronic wound healing process. Based on the introduction of the related concept of circRNA, this paper focuses on the possible regulatory mechanism of circRNA in different stages of diabetic wound healing and summarizes the potential role of circRNA in the process of diabetic peripheral vascular atherosclerosis, aiming to explore the in-depth molecular mechanism and clinical significance of circRNA in diabetic wound healing process, and provide reference for further research.
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Key words:
- Diabetes mellitus /
- Wound healing /
- Circular RNA /
- Mechanism of action
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