脂肪干细胞促进创面修复的机制与应用进展

孙天艺; 鲁峰; 高建华; 周澄; 董自清; 李玢

doi:10.3760/cma.j.cn501225-20220729-00320

脂肪干细胞促进创面修复的机制与应用进展

doi: 10.3760/cma.j.cn501225-20220729-00320

南方医科大学南方医院整形美容外科，广州　　510515

基金项目:

国家自然科学基金青年科学基金项目 81801932

广东省基础与应用基础研究基金 2022A1515011232

详细信息

通讯作者:
李玢，Email：binbinxiaoli@126.com

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出版历程
- 收稿日期: 2022-07-29

Progress on the mechanism and application of adipose-derived stem cells in promoting wound repair

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

Funds:

Youth Science Foundation Project of of National Natural Science Foundation of China 81801932

Guangdong Basic and Applied Basic Research Foundation 2022A1515011232

More Information

Corresponding author: Li Bin, Email: binbinxiaoli@126.com

摘要

摘要: 创面修复异常所导致的慢性难愈性创面及瘢痕严重损害了患者身体健康，影响了患者生活质量，且目前缺乏简单有效、经济的治疗手段。脂肪干细胞（ASC）作为一种拥有多向分化潜能的间充质干细胞，已经被多项体内、体外研究证实可以通过促上皮化、促血管生成、免疫调节和抗氧化等机制促进创面愈合。ASC及其衍生物已被用于治疗由烧伤、糖尿病和放射性损伤等导致的难愈性创面并取得良好效果，且其成为创面修复新材料的潜力也得到了证实。该文就ASC促进创面修复的机制和临床应用进行综述，并对其研究方向与前景进行展望。
- 间质干细胞 /
- 新生血管化，生理性 /
- 干细胞移植 /
- 脂肪干细胞 /
- 慢性创面 /
- 创面修复
Abstract: Chronic refractory wounds and scars caused by abnormal wound repair seriously damage the health of patients and affect their quality of life. At present, there is a lack of simple but effective and economical treatment methods. Adipose-derived stem cells (ASCs), as a kind of mesenchymal stem cells with multi-directional differentiation potential, have been confirmed by several in vivo and in vitro studies to promote wound healing by promoting epithelialization, angiogenesis, immunoregulation, antioxidant properties, and other mechanisms. ASCs and their derivatives have been used in the treatment of refractory wounds caused by burns, diabetic, and radiation injuries with good results achieved. Their potential to become new materials for wound repair has also been confirmed. This paper reviewed the mechanism and clinical application of ASCs in promoting wound repair, and looked into its research direction and prospects.
- Mesenchymal stem cells /
- Neovascularization, physiologic /
- Stem cell transplantation /
- Adipose-derived stem cell /
- Chronic wound /
- Wound repair
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参考文献(49)

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