负载纳米酶的组织工程支架在创面修复中的应用与进展

郝瑞南; 叶熙林; 徐柏龙; 孙芸; 刘惠玉; 饶烽; 薛佳佳

doi:10.3760/cma.j.cn501225-20220806-00337

负载纳米酶的组织工程支架在创面修复中的应用与进展

doi: 10.3760/cma.j.cn501225-20220806-00337

1.
有机无机复合材料国家重点实验室，生物医用材料北京实验室，先进弹性体材料研究中心，北京化工大学材料科学与工程学院，北京　　100029
2.
北京市软物质科学与工程先进创新中心,生物纳米材料与转化工程实验室,生物过程北京市重点实验室,北京化工大学生物医学材料实验室,北京　　100029
3.
北京大学人民医院创伤中心，国家创伤医学中心，北京　　100044

基金项目:

国家自然科学基金青年科学基金项目 82002049

中央高校基本科研经费专项资金 buctrc202020

详细信息

通讯作者:
薛佳佳，Email：jiajiaxue@mail.buct.edu.cn

计量
- 文章访问数: 173
- HTML全文浏览量: 47
- PDF下载量: 40
- 被引次数: 0
出版历程
- 收稿日期: 2022-08-06
- 网络出版日期: 2023-06-25

Application and advances of nanozyme-loaded tissue engineering scaffolds in wound repair

1.
State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Center of Advanced Elastomer Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
2.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, BionanomaterialsTranslational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
3.
Trauma Center, Peking University People's Hospital, National Center for Trauma Medicine, Beijing 100044, China

Funds:

Youth Science Foundation Program of National Natural Science Foundation of China 82002049

Special Funds for Fundamental Scientific Research Expenses of Central Universities buctrc202020

More Information

Corresponding author: Xue Jiajia, Email: jiajiaxue@mail.buct.edu.cn

摘要

摘要: 有效重建受损皮肤组织并恢复其完整性和功能性仍是当前创伤修复领域面临的重要医学问题。近年来，纳米酶和组织工程支架在再生医学领域的飞速发展，使得开发新型皮肤创伤修复材料成为可能。该综述立足于皮肤创伤修复与再生过程，简述了纳米酶及其催化机制，同时介绍了常见的负载纳米酶的组织工程支架及其制造策略，总结了负载纳米酶的组织工程支架在创面修复过程中抗菌、抗炎等阶段的应用并探讨了其未来发展方向。
- 生物相容性材料 /
- 组织工程 /
- 支架 /
- 纳米酶 /
- 创伤修复 /
- 皮肤再生
Abstract: At present, effective reconstruction of the integrity and functionality of damaged skin tissue remains an important medical problem in the field of wound repair. In recent years, the rapid development of nanozymes and tissue engineering scaffolds in the field of regenerative medicine has made it possible to develop new skin wound repair materials. Based on the process of skin wound repair and regeneration, this review briefly describes the nanozymes and its catalytic mechanism. At the same time, the common tissue engineering scaffolds loaded with nanozymes and their manufacturing strategies are introduced, the application of tissue engineering scaffolds loaded with nanozymes during the stages of anti-bacteria and anti-inflammation in the process of wound repair is summarized, and their future development direction is discussed.
- Biocompatible materials /
- Tissue engineering /
- Stents /
- Nanozymes /
- Wound repair /
- Skin regeneration
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