Wnt/<b>β</b>连环蛋白信号通路在体表创面愈合中的作用机制研究进展

伍倩; 谭晓宇; 王怡佳; 程少文; 崔红旺; 姚江凌

doi:10.3760/cma.j.cn501225-20220816-00348

Wnt/β连环蛋白信号通路在体表创面愈合中的作用机制研究进展

doi: 10.3760/cma.j.cn501225-20220816-00348

1.
海南医学院，海口　　570105
2.
海南医学院第一附属医院急诊和创伤外科，海口　　570102

基金项目:

国家自然科学基金地区科学基金 82260373, 81860347

海南省自然科学基金 822QN463, 822MS174

海南省卫生健康行业科研项目 21A200062, 21A200231

海南医学院第一附属医院青年培育基金 HYYFYPY202005

海南医学院大学生创新创业训练计划项目 X202211810008

详细信息

通讯作者:
姚江凌，Email：yaojiangling917@126.com

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出版历程
- 收稿日期: 2022-08-16

Research advances on the mechanism of Wnt/β-catenin signaling pathway in body surface wound healing

1.
Hainan Medical University, Haikou 570105, China
2.
Department of Emergency and Trauma Surgery, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, China

Funds:

Regional Science Foundation of National Natural Science Foundation of China 82260373, 81860347

Natural Science Foundation of Hainan Province of China 822QN463, 822MS174

Research Project of Health Industry in Hainan Province of China 21A200062, 21A200231

Youth Development Fund of the First Affiliated Hospital of Hainan Medical University HYYFYPY202005

Innovative Entrepreneurship Training Program for Hainan Medical University College Students X202211810008

More Information

Corresponding author: Yao Jiangling, Email: yaojiangling917@126.com

摘要

摘要: 创面愈合是一个缓慢而复杂的生物学过程，包括炎症反应、细胞增殖分化和迁移、血管新生、细胞外基质沉积和组织重塑等。Wnt信号通路可分为经典通路和非经典通路，其中Wnt经典通路又称Wnt/β连环蛋白信号通路，其在细胞分化、迁移和组织稳态维持过程中发挥重要作用。许多炎症因子、生长因子等都参与该通路的上游调控。Wnt/β连环蛋白信号通路的激活在皮肤创面的发生、发展、再生、修复及相关治疗的过程中，起到了重要作用。该文综述了Wnt/β连环蛋白信号通路与创面愈合的关系，并总结了其对炎症反应、细胞增殖、血管新生、毛囊再生和皮肤纤维化等创面愈合重要过程的影响以及Wnt信号通路抑制因子在创面愈合中的作用。
- 皮肤 /
- Wnt信号通路 /
- 伤口愈合 /
- 细胞增殖 /
- β连环蛋白
Abstract: Wound healing is a slow and complex biological process, including inflammatory reaction, cell proliferation, cell differentiation, cell migration, angiogenesis, extracellular matrix deposition, tissue remodeling, and so on. Wnt signaling pathway can be divided into classical pathway and non-classical pathway. Wnt classical pathway, also known as Wnt/β-catenin signaling pathway, plays an important role in cell differentiation, cell migration, and maintenance of tissue homeostasis. Many inflammatory factors and growth factors are involved in the upstream regulation of this pathway. The activation of Wnt/β-catenin signaling pathway plays an important role in the occurrence, development, regeneration, repair and related treatment of skin wounds. This article review the relationship between Wnt/β-catenin signaling pathway and wound healing, meanwhile summarizes its effects on important processes of wound healing, such as inflammation, cell proliferation, angiogenesis, hair follicle regeneration, and skin fibrosis, as well as the role of inhibitors of Wnt signaling pathway in wound healing.
- Skin /
- Wnt signaling pathway /
- Wound healing /
- Cell proliferation /
- β-catenin protein
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