提高间充质干细胞外泌体创面修复疗效的研究进展

段育任; 赵雨晨; 宋文禹; 王佳欣; 裴洁; 王小兵

doi:10.3760/cma.j.cn501225-20220912-00402

提高间充质干细胞外泌体创面修复疗效的研究进展

doi: 10.3760/cma.j.cn501225-20220912-00402

1.
山西医科大学第一医院烧伤整形科，太原　　030001
2.
咸阳市中心医院烧伤整形科，咸阳　　712099
3.
山西白求恩医院（山西医学科学院　同济山西医院），山西医科大学第三医院整形外科，太原　　030032

基金项目:

山西省基础研究计划青年科学研究项目 202103021223412

详细信息

通讯作者:
王小兵，Email：xiaobingw1970@163.com

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出版历程
- 收稿日期: 2022-09-12
- 网络出版日期: 2023-07-19

Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair

1.
Department of Burns and Plastic Surgery, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
2.
Department of Burns and Plastic Surgery, Xianyang Central Hospital, Xianyang 712099, China
3.
Department of Plastic Surgery, Shanxi Bethune Hospital (Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), the Third Hospital of Shanxi Medical University, Taiyuan 030032, China

Funds:

Shanxi Provincial Basic Research Program Youth Science Research Project 202103021223412

More Information

Corresponding author: Wang Xiaobing, Email: xiaobingw1970@163.com

摘要

摘要: 如何促进创面高质量愈合是整形外科和烧伤科医师共同面临的问题。近年来，大量动物研究表明间充质干细胞外泌体通过多种机制促进创面修复，是具有广阔应用前景的无细胞治疗剂。如何强化外泌体治疗效力、优化其给药策略、改善其生物性能，是外泌体治疗创面从基础研究推向临床应用所需攻克的难关。该文着重探讨提高间充质干细胞外泌体创面修复潜力的方法，从预处理亲本间充质干细胞、水凝胶生物支架装载外泌体、工程化外泌体3个方面综述了近年来提高间充质干细胞外泌体创面修复疗效的研究进展，为后续临床研究提供参考。
- 间充质干细胞 /
- 外泌体 /
- 水凝胶 /
- 创面修复
Abstract: How to promote high-quality wound healing is a common problem for plastic surgery and burn physicians. In recent years, numerous animal studies have demonstrated that mesenchymal stem cell-derived exosomes promote wound repair through multiple mechanisms and are promising cell-free therapeutic agents with broad prospect of application. How to enhance the therapeutic efficacy of exosomes, optimize their drug delivery strategy, and improve their biological properties are the challenges to be overcome in order to move from basic research to clinical application of exosome therapy for wound repair. This article focuses on methods to improve the wound repair potential of mesenchymal stem cell-derived exosomes, and reviews the recent research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair from three aspects, including pretreatment of parental mesenchymal stem cells, hydrogel bio-scaffold loaded with exosomes, and engineered exosomes, to provide a reference for further clinical studies.
- Mesenchymal stem cells /
- Exosomes /
- Hydrogel /
- Wound repair
所有作者均声明不存在利益冲突

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参考文献(40)

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