Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair
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摘要: 如何促进创面高质量愈合是整形外科和烧伤科医师共同面临的问题。近年来,大量动物研究表明间充质干细胞外泌体通过多种机制促进创面修复,是具有广阔应用前景的无细胞治疗剂。如何强化外泌体治疗效力、优化其给药策略、改善其生物性能,是外泌体治疗创面从基础研究推向临床应用所需攻克的难关。该文着重探讨提高间充质干细胞外泌体创面修复潜力的方法,从预处理亲本间充质干细胞、水凝胶生物支架装载外泌体、工程化外泌体3个方面综述了近年来提高间充质干细胞外泌体创面修复疗效的研究进展,为后续临床研究提供参考。Abstract: How to promote high-quality wound healing is a common problem for plastic surgery and burn physicians. In recent years, numerous animal studies have demonstrated that mesenchymal stem cell-derived exosomes promote wound repair through multiple mechanisms and are promising cell-free therapeutic agents with broad prospect of application. How to enhance the therapeutic efficacy of exosomes, optimize their drug delivery strategy, and improve their biological properties are the challenges to be overcome in order to move from basic research to clinical application of exosome therapy for wound repair. This article focuses on methods to improve the wound repair potential of mesenchymal stem cell-derived exosomes, and reviews the recent research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair from three aspects, including pretreatment of parental mesenchymal stem cells, hydrogel bio-scaffold loaded with exosomes, and engineered exosomes, to provide a reference for further clinical studies.
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Key words:
- Mesenchymal stem cells /
- Exosomes /
- Hydrogel /
- Wound repair
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