Research advances on conductive hydrogels and their applications in the repair of diabetic wounds
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摘要: 导电水凝胶作为一种新型功能性创面敷料，因具有适宜的电导率、良好的保湿性、优异的生物相容性，以及介导细胞迁移和增殖、促进血管生成和胶原沉积等生物学作用，在创面修复领域具有广阔的应用前景。通过结合临床上的电刺激疗法，导电水凝胶初步体现出促进肉芽组织形成、再上皮化和创面愈合的疗效，为糖尿病创面修复提供了新的治疗思路。该文基于不同的导电机制，总结了近年来电子导电型水凝胶和离子导电型水凝胶的研究进展，同时特别介绍了导电水凝胶在糖尿病创面修复中的应用情况，并对未来导电水凝胶创面敷料的发展进行展望。Abstract: As a new type of functional wound dressing, conductive hydrogel, shows broad prospects of application in the field of wound repair due to its suitable electrical conductivity, good moisture retention, excellent biocompatibility, and biological effects such as mediating cell migration and proliferation, and promoting angiogenesis and collagen deposition. Combined with the clinical electrical stimulation therapy, the conductive hydrogel primarily showed curative effects of promoting granulation tissue formation, re-epithelialization, and wound healing, providing a new treatment idea for the repair of diabetic wounds. This review summarized the research advances of electronic conductive hydrogels and ionic conductive hydrogels in recent years based on different conductive mechanisms. Meanwhile, the applications of conductive hydrogel in the diabetic wound repair were specifically introduced, and the future development of conductive hydrogel wound dressing was prospected.
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