Research advances on the mechanism of non-coding RNA regulated diabetic wound healing
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摘要: 糖尿病创面是糖尿病患者的常见并发症,近年来其发病率不断上升,且临床预后较差,严重影响患者的生活质量,逐渐成为糖尿病治疗的重点和难点。非编码RNA作为调控基因表达的RNA,可调控许多疾病的病理生理过程,在糖尿病创面的愈合过程中起着重要作用。该文对3种常见非编码RNA在糖尿病创面愈合过程中的调控作用、诊断价值、治疗潜力进行了综述,从基因层面和分子水平上为糖尿病创面的诊疗提供了新思路。Abstract: Diabetic wounds are a common complication of diabetic patients, and the incidence has been increasing in recent years. In addition, its poor clinical prognosis seriously affects the quality of life of patients, which has become the focus and difficulty of diabetes treatment. As the RNA regulating gene expression, non-coding RNA can regulate the pathophysiological process of diseases, and play an important role in the healing process of diabetic wounds. In this paper, we reviewed the regulatory role, diagnostic value, and therapeutic potential of three common non-coding RNA in diabetic wounds, in order to provide a new solution for the diagnosis and treatment of diabetic wounds at the genetic and molecular level.
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Key words:
- Diabetes mellitus /
- RNA, long noncoding /
- Wound healing
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