大面积烧伤患者精神障碍研究进展

顾国鑫; 冉明梓; 李萌萌

doi:10.3760/cma.j.cn501225-20221116-00490

大面积烧伤患者精神障碍研究进展

doi: 10.3760/cma.j.cn501225-20221116-00490

1.
锦州医科大学研究生院，锦州　　121000
2.
解放军总医院第四医学中心麻醉科，北京　　100089

详细信息

通讯作者:
李萌萌，Email：mmli304@163.com

计量
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- HTML全文浏览量: 59
- PDF下载量: 37
- 被引次数: 0
出版历程
- 收稿日期: 2022-11-16
- 网络出版日期: 2023-10-26

Research advances on mental disorders in patients with extensive burns

1.
Graduate School of Jinzhou Medical University, Jinzhou 121000, China
2.
Department of Anesthesiology, the Fourth Medical Center of PLA General Hospital, Beijing 100089, China

More Information

Corresponding author: Li Mengmeng, Email: mmli304@163.com

摘要

摘要: 大面积烧伤会对患者中枢神经系统造成不可忽视的急慢性损伤。中枢神经的损伤会对患者产生深远的影响，造成创伤后应激障碍、抑郁、焦虑和睡眠障碍等神经行为学改变，这些改变在伤后可能持续存在，极大地影响患者融入社会、重返工作。该文系统综述大面积烧伤患者精神障碍的临床表现、发生机制及目前的干预方法，旨在为进一步认识、预防及治疗烧伤患者精神障碍提供依据。
- 烧伤 /
- 精神障碍 /
- 药物疗法 /
- 非药物疗法 /
- 机制
Abstract: Extensive burns can cause nonnegligible acute and chronic damage to central nervous system of patients. The damage of central nervous system may have a profound impact on patients, including neurobehavioral changes such as post-traumatic stress disorder, depression, anxiety, and sleep disorder. These changes may persist after injury, greatly affecting patients' integration into society and return to work. This paper systematically reviewed the clinical manifestations, pathogenesis, and current intervention methods of mental disorders in patients with extensive burns, aiming to provide a basis for further understanding, prevention, and treatment of patients with mental disorders after burns.
- Burns /
- Mental disorders /
- Drug therapy /
- Non-drug therapy /
- Mechanism
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参考文献(42)

[1]	邱筱婷,邵珂,李延菲,等.外科烧伤患者营养管理的研究进展[J/CD].临床普外科电子杂志,2019,7(3):33-42.DOI: 10.3969/j.issn.2095-5308.2019.03.008.
[2]	王良梅,吴大国,张莉,等.合理情绪行为干预模式对大面积烧伤患者焦虑、抑郁及生活质量评分的影响[J].实用医院临床杂志,2019,16(1):125-127.DOI: 10.3969/j.issn.1672-6170.2019.01.040.
[3]	FardinA,RezaeiSA,MaslakpakMH.Non-pharmacological interventions for anxiety in burn patients: a systematic review and meta-analysis of randomized controlled trials[J].Complement Ther Med,2020,49:102341.DOI: 10.1016/j.ctim.2020.102341.
[4]	BichCS,KostevK,BausA,et al.Burn injury and incidence of psychiatric disorders: a retrospective cohort study of 18,198 patients from Germany[J].Burns,2021,47(5):1110-1117.DOI: 10.1016/j.burns.2020.06.015.
[5]	卢小莲,吕燕,黄斌.烧伤临床早期病人焦虑发生情况及其影响因素调查[J].护理学杂志,2003,18(3):208-209.DOI: 10.3969/j.issn.1001-4152.2003.03.030.
[6]	KhanK,NajmiAK,AkhtarM.A natural phenolic compound quercetin showed the usefulness by targeting inflammatory, oxidative stress markers and augment 5-HT levels in one of the animal models of depression in mice[J].Drug Res (Stuttg),2019,69(7):392-400.DOI: 10.1055/a-0748-5518.
[7]	EdwardsRR,Magyar-RussellG,ThombsB,et al.Acute pain at discharge from hospitalization is a prospective predictor of long-term suicidal ideation after burn injury[J].Arch Phys Med Rehabil,2007,88(12 Suppl 2):S36-42.DOI: 10.1016/j.apmr.2007.05.031.
[8]	MenziesV.Depression and burn wounds[J].Arch Psychiatr Nurs,2000,14(4):199-206.DOI: 10.1053/apnu.2000.8660.
[9]	SuYJ,ChowCC.PTSD, depression and posttraumatic growth in young adult burn survivors: three-year follow-up of the 2015 Formosa fun coast water park explosion in Taiwan[J].J Affect Disord,2020,274:239-246.DOI: 10.1016/j.jad.2020.05.025.
[10]	McLeanL,ChenR,KwietJ,et al.A clinical update on posttraumatic stress disorder in burn injury survivors[J].Australas Psychiatry,2017,25(4):348-350.DOI: 10.1177/1039856217700285.
[11]	ThibautA,ShieVL,RyanCM,et al.A review of burn symptoms and potential novel neural targets for non-invasive brain stimulation for treatment of burn sequelae[J].Burns,2021,47(3):525-537.DOI: 10.1016/j.burns.2020.06.005.
[12]	LermanSF,SylvesterS,HultmanCS,et al.Suicidality after burn injuries: a systematic review[J].J Burn Care Res,2021,42(3):357-364.DOI: 10.1093/jbcr/irab014.
[13]	戴倩莹,梁银爱,龚灵芝,等.烧伤患者创面瘙痒症状对睡眠质量影响的临床研究[J].临床护理杂志,2022,21(1):8-11.DOI: 10.3969/j.issn.1671-8933.2022.01.003.
[14]	ChungBY,KimHB,JungMJ,et al.Post-burn pruritus[J].Int J Mol Sci,2020,21(11):3880. DOI: 10.3390/ijms21113880.
[15]	GeorgeB, SuchithraTV, BhatiaN. Burn injury induces elevated inflammatory traffic: the role of NF-κB[J]. Inflamm Res, 2021,70(1):51-65. DOI: 10.1007/s00011-020-01426-x.
[16]	张庆红,费翔,董宁,等.高迁移率族蛋白B1在烧伤小鼠大脑中表达的研究[J].感染、炎症、修复,2012,13(3):131-133,封2.DOI: 10.3969/j.issn.1672-8521.2012.03.001.
[17]	杜艺炜,夏玉洁,林杉杉,等.神经源性外泌体在精神疾病中作用的研究进展[J].神经疾病与精神卫生,2023,23(8):593-598.DOI: 10.3969/j.issn.1009-6574.2023.08.010.
[18]	王水明,刘友生,陈锐.大鼠严重烧伤后大脑皮质神经元和腓肠肌细胞bcl-2、HSP70蛋白的表达及意义[J].中国组织化学与细胞化学杂志,2002,11(3):256-258.DOI: 10.3870/j.issn.1004-1850.2002.03.005.
[19]	刘曾旭,刘德明,王向东.一氧化氮在严重烧伤后脑组织中的作用[J].解剖科学进展,2005,11(4):354-357.DOI: 10.3969/j.issn.1006-2947.2005.04.022.
[20]	MaL,ZhouY,KhanM,et al.Burn-induced microglia activation is associated with motor neuron degeneration and muscle wasting in mice[J].Shock,2019,51(5):569-579.DOI: 10.1097/SHK.0000000000001300.
[21]	吴孝苹,王东,陈忠伦,等.焦虑抑郁情绪对烧伤后血小板5-羟色胺水平、血小板计数和细胞因子的影响[J].中国循证医学杂志,2012,12(9):1047-1051.DOI: 10.3969/j.issn.1672-2531.2012.09.003.
[22]	杨劼,张翠萍,马奎,等.间充质干细胞在血脑屏障损伤修复中的作用及相关研究进展[J].感染、炎症、修复,2018,19(4):250-253,256.DOI: 10.3969/j.issn.1672-8521.2018.04.013.
[23]	YangJ,MaK,ZhangC,et al.Burns impair blood-brain barrier and mesenchymal stem cells can reverse the process in mice[J].Front Immunol,2020,11:578879.DOI: 10.3389/fimmu.2020.578879.
[24]	刘彤,任宪奔,李营,等.爆震伤对大鼠神经功能的损伤作用及机制探讨[J].临床外科杂志,2020,28(10):917-919.DOI: 10.3969/j.issn.1005-6483.2020.10.007.
[25]	ZhangQH,HaoJW,LiGL,et al.Long-lasting neurobehavioral alterations in burn-injured mice resembling post-traumatic stress disorder in humans[J].Exp Neurol,2020,323:113084.DOI: 10.1016/j.expneurol.2019.113084.
[26]	OstaWA,El-OstaMA,PezhmanEA,et al.Nicotinic acetylcholine receptor gene expression is altered in burn patients[J].Anesth Analg,2010,110(5):1355-1359.DOI: 10.1213/ANE.0b013e3181d41512.
[27]	贾媛,赵华兴,李行,等.烧伤患者创面感染的研究进展[J].临床与病理杂志,2019,39(3):634-639.DOI: 10.3978/j.issn.2095-6959.2019.03.029.
[28]	卫逸君,张安琪,邵一帆,等. 抑郁对大鼠肠道菌群的影响研究[J]. 解放军预防医学杂志,2021,39(1):1-4.
[29]	MinerbiA,ShenS.Gut microbiome in anesthesiology and pain medicine[J].Anesthesiology,2022,137(1):93-108.DOI: 10.1097/ALN.0000000000004204.
[30]	ZhangL, MengJ, BanY,et al. Morphine tolerance is attenuated in germfree mice and reversed by probiotics, implicating the role of gut microbiome[J]. Proc Natl Acad Sci U S A, 2019,116(27):13523-13532. DOI: 10.1073/pnas.1901182116.
[31]	陈旭.烧伤患者焦虑及抑郁的药物与心理治疗[J].中国卫生标准管理,2022,13(8):53-55.DOI: 10.3969/j.issn.1674-9316.2022.08.015.
[32]	DingX,LuoY,ShiL,et al.Butorphanol in combination with dexmedetomidine provides efficient pain management in adult burn patients[J].Burns,2021,47(7):1594-1601.DOI: 10.1016/j.burns.2020.12.025.
[33]	徐风瑞,李玉,杨帆,等.右美托咪啶及芬太尼在减轻烧伤患者应激反应中的作用[J].现代医学,2018,46(7):758-761.DOI: 10.3969/j.issn.1671-7562.2018.07.007.
[34]	周盼盼.逍遥散抗抑郁药理研究进展[J].光明中医,2022,37(9):1693-1696.DOI: 10.3969/j.issn.1003-8914.2022.09.063.
[35]	LiuM, SongS, ChenQ, et al. Gut microbiota mediates cognitive impairment in young mice after multiple neonatal exposures to sevoflurane[J]. Aging (Albany NY), 2021,13(12):16733-16748. DOI: 10.18632/aging.203193.
[36]	WangP, YinX, ChenG, et al. Perioperative probiotic treatment decreased the incidence of postoperative cognitive impairment in elderly patients following non-cardiac surgery: a randomised double-blind and placebo-controlled trial[J]. Clin Nutr, 2021,40(1):64-71. DOI: 10.1016/j.clnu.2020.05.001.
[37]	李香粉,刘畅,闫乐婷,等.迷走神经刺激改善抑郁症患者临床症状的机制[J].中国神经精神疾病杂志,2023,49(5):313-317.DOI: 10.3969/j.issn.1002-0152.2023.05.011.
[38]	闫美丽.重复经颅磁刺激联合抗抑郁药物治疗伴焦虑痛苦症状抑郁症患者的疗效和安全性[J].湖北科技学院学报(医学版),2023,37(4):332-334.DOI: 10.16751/j.cnki.2095-4646.2023.04.0332.
[39]	杨自强,周丽萍. 应用烧烫康治疗烧伤病人100例临床体会[J/CD]. 世界最新医学信息文摘(连续型电子期刊),2017,17(53):155,157. DOI: 10.3969/j.issn.1671-3141.2017.53.117.
[40]	杜彩凤,李华.认知行为疗法对深Ⅱ度烧伤患者心理状态、疼痛及并发症的影响[J].中国健康心理学杂志,2021,29(7):978-983.DOI: 10.13342/j.cnki.cjhp.2021.07.005.
[41]	Najafi GhezeljehT,Mohades ArdebiliF,RafiiF.The effects of massage and music on pain, anxiety and relaxation in burn patients: randomized controlled clinical trial[J].Burns,2017,43(5):1034-1043.DOI: 10.1016/j.burns.2017.01.011.
[42]	马玉红,宁红彤,宋佳,等.香薰按摩治疗抑郁症现状研究[J].中国中医药现代远程教育,2022,20(11):205-206,后插1,封3.DOI: 10.3969/j.issn.1672-2779.2022.11.079.