胰石蛋白在脓毒症早期诊断中应用的研究进展

何婷; 刘伟; 申传安

doi:10.3760/cma.j.cn501225-20221120-00498

胰石蛋白在脓毒症早期诊断中应用的研究进展

doi: 10.3760/cma.j.cn501225-20221120-00498

解放军总医院第四医学中心烧伤整形医学部，北京　　100048

基金项目:

国家自然科学基金面上项目 82072169, 82272279

军队后勤科研项目保健专项 22BJZ35

军队后勤科研重大项目 ALB18J001

详细信息

通讯作者:
申传安，Email：shenchuanan@126.com

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- 被引次数: 0
出版历程
- 收稿日期: 2022-11-20
- 网络出版日期: 2023-10-26

Research advances on application of pancreatic stone protein in the early diagnosis of sepsis

Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China

Funds:

General Program of National Natural Science Foundation of China 82072169, 82272279

Military Logistics Scientific Research Project Health Special Project 22BJZ35

Major Program of Military Logistics Research Plan ALB18J001

More Information

Corresponding author: Shen Chuan'an, Email: shenchuanan@126.com

摘要

摘要: 脓毒症是一种严重危及生命的综合征，其主要特征是宿主对感染的异常反应，可迅速演变为脓毒症休克和多器官功能衰竭。脓毒症的治疗依赖于早期识别和诊断以及充分而及时的抗感染和多器官功能支持。近年来，胰石蛋白作为一种新的脓毒症生物标志物被广泛研究。现有证据表明，与目前临床上常用的炎症标志物相比，胰石蛋白对脓毒症的诊断具有更高的敏感度和特异度，并且能对脓毒症进行早期识别，可在一定程度上评估脓毒症患者病情的严重程度。该文就胰石蛋白的特征、生物学功能、诊断特点以及临床应用的研究进展作一综述。
- 脓毒症 /
- 胰石蛋白 /
- 感染 /
- 诊断
Abstract: Sepsis is a severe life-threatening syndrome characterized by an abnormal host response to infection that can rapidly evolve into septic shock and multiple organ failure. Treatment of sepsis depends on early identification and diagnosis as well as adequate and timely anti-infection and multi-organ functional support. In recent years, pancreatic stone protein has been widely studied as a new biomarker for sepsis. Existing evidence shows that compared with the commonly used inflammatory markers in clinical practice, pancreatic stone protein has higher sensitivity and specificity in the diagnosis of sepsis. It enables the early diagnosis of sepsis and assessment of the severity of septic patients to a certain extent. This article reviews the characteristics, biological functions, diagnostic features, and clinical application of pancreatic stone protein.
- Sepsis /
- Lithostathine /
- Infection /
- Diagnosis
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参考文献(37)

[1]	姚咏明,张卉.改善脓毒症患者长期预后的康复治疗对策[J].中华烧伤与创面修复杂志,2022,38(3):201-206.DOI: 10.3760/cma.j.cn501120-20211004-00344.
[2]	曾茁,彭毅志,袁志强.脓毒症生物标志物的研究进展[J].中华烧伤与创面修复杂志,2023,39(7):679-684.DOI: 10.3760/cma.j.cn501225-20230320-00086.
[3]	FidalgoP, NoraD, CoelhoL, et al. Pancreatic stone protein: review of a new biomarker in sepsis[J]. J Clin Med, 2022, 11(4): 1085. DOI: 10.3390/jcm11041085.
[4]	GrafR.Pancreatic stone protein - sepsis and the riddles of the exocrine pancreas[J].Pancreatology,2020,20(3):301-304.DOI: 10.1016/j.pan.2020.01.016.
[5]	SchlapbachLJ,GiannoniE,WellmannS,et al.Normal values for pancreatic stone protein in different age groups[J].BMC Anesthesiol,2015,15:168.DOI: 10.1186/s12871-015-0149-y.
[6]	KeelM,HärterL,RedingT,et al.Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes[J].Crit Care Med,2009,37(5):1642-1648.DOI: 10.1097/CCM.0b013e31819da7d6.
[7]	StoneS,AbreuD,MahadevanJ,et al.Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells[J].Sci Rep,2019,9(1):5199.DOI: 10.1038/s41598-019-41604-4.
[8]	LiL,BimmlerD,GrafR,et al.PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio[J].Eur J Clin Invest,2011,41(2):151-158.DOI: 10.1111/j.1365-2362.2010.02390.x.
[9]	JinCX,HayakawaT,KoSB,et al.Pancreatic stone protein/regenerating protein family in pancreatic and gastrointestinal diseases[J].Intern Med,2011,50(15):1507-1516.DOI: 10.2169/internalmedicine.50.5362.
[10]	PathakA,AgrawalA. Evolution of C-reactive protein[J].Front Immunol,2019,10:943.DOI: 10.3389/fimmu.2019.00943.
[11]	姚咏明,张卉,童亚林.深化对烧伤脓毒症诊断体系与治疗策略的认识[J].中华烧伤杂志,2021,37(5):404-409.DOI: 10.3760/cma.j.cn501120-20200703-00337.
[12]	WuQ, NieJ, WuFX, et al. Prognostic value of high-sensitivity C-reactive protein, procalcitonin and pancreatic stone protein in pediatric sepsis[J]. Med Sci Monit, 2017, 23: 1533-1539. DOI: 10.12659/msm.900856.
[13]	HamadeB,HuangDT.Procalcitonin: where are we now?[J].Crit Care Clin,2020,36(1):23-40.DOI: 10.1016/j.ccc.2019.08.003.
[14]	Mierzchała-PasierbM,Lipińska-GedigaM.Sepsis diagnosis and monitoring - procalcitonin as standard, but what next?[J].Anaesthesiol Intensive Ther,2019,51(4):299-305.DOI: 10.5114/ait.2019.88104.
[15]	HuPY,ChenYM,PangJL,et al.Association between IL-6 polymorphisms and sepsis[J].Innate Immun,2019,25(8):465-472.DOI: 10.1177/1753425919872818.
[16]	ZengGB,ChenD,ZhouRX,et al.Combination of C-reactive protein, procalcitonin, IL-6, IL-8, and IL-10 for early diagnosis of hyperinflammatory state and organ dysfunction in pediatric sepsis[J].J Clin Lab Anal,2022,36(7):e24505.DOI: 10.1002/jcla.24505.
[17]	XiangZY,ChenXD,ZhouXM,et al.Development and application of a novel aldehyde nanoparticle-based amplified luminescent proximity homogeneous assay for rapid quantitation of pancreatic stone protein[J].Clin Chim Acta,2022,535:120-130. DOI: 10.1016/j.cca.2022.08.020.
[18]	PuginJ,DaixT,PaganiJL,et al.Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study[J].Crit Care,2021,25(1):151.DOI: 10.1186/s13054-021-03576-8.
[19]	KleinHJ, NiggemannP, BuehlerPK, et al. Pancreatic stone protein predicts sepsis in severely burned patients irrespective of trauma severity: a monocentric observational study[J]. Ann Surg, 2021, 274(6): e1179-e1186. DOI: 10.1097/SLA.0000000000003784.
[20]	EggimannP,QueYA,RebeaudF.Measurement of pancreatic stone protein in the identification and management of sepsis[J].Biomark Med,2019,13(2):135-145.DOI: 10.2217/bmm-2018-0194.
[21]	TatemichiN,TakahashiC,HayakawaS,et al.Enzyme immunoassay and characterization of pancreatic stone proteins in human urine[J].J Clin Lab Anal,1993,7(6):365-370.DOI: 10.1002/jcla.1860070611.
[22]	GrafR,SchiesserM,LüssiA,et al.Coordinate regulation of secretory stress proteins (PSP/reg, PAP Ⅰ, PAP Ⅱ, and PAP Ⅲ) in the rat exocrine pancreas during experimental acute pancreatitis[J].J Surg Res,2002,105(2):136-144.DOI: 10.1006/jsre.2002.6387.
[23]	PalmiereC,AugsburgerM.Pancreatic stone protein as a postmortem biochemical marker for the diagnosis of sepsis[J].Leg Med (Tokyo),2015,17(1):9-13.DOI: 10.1016/j.legalmed.2014.08.003.
[24]	QueYA,DelodderF,GuessousI,et al.Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management[J].Crit Care,2012,16(4):R114.DOI: 10.1186/cc11406.
[25]	RassAA, TalatMA, ArafaMA, et al. The role of pancreatic stone protein in diagnosis of early onset neonatal sepsis[J]. Biomed Res Int, 2016, 2016: 1035856. DOI: 10.1155/2016/1035856.
[26]	LagadinouM,ParaskevasT,VelissarisD,et al.The role of pancreatic stone protein as a prognostic factor for COVID-19 patients[J].Eur Rev Med Pharmacol Sci,2022,26(17):6391-6395.DOI: 10.26355/eurrev_202209_29666.
[27]	NiggemannP, RittirschD, BuehlerPK, et al. Incidence and time point of sepsis detection as related to different sepsis definitions in severely burned patients and their accompanying time course of pro-inflammatory biomarkers[J]. J Pers Med, 2021, 11(8): 701. DOI: 10.3390/jpm11080701.
[28]	KleinHJ,CsordasA,FalkV,et al.Pancreatic stone protein predicts postoperative infection in cardiac surgery patients irrespective of cardiopulmonary bypass or surgical technique[J].PLoS One,2015,10(3):e0120276.DOI: 10.1371/journal.pone.0120276.
[29]	GukasjanR,RaptisDA,SchulzHU,et al.Pancreatic stone protein predicts outcome in patients with peritonitis in the ICU[J].Crit Care Med,2013,41(4):1027-1036.DOI: 10.1097/CCM.0b013e3182771193.
[30]	黄云峰,周帆,徐晓林.胰石蛋白在呼吸机相关性肺炎患者支气管肺泡灌洗液及呼出气冷凝液中的表达及检测价值[J].实用临床医药杂志,2019,23(11):99-102.DOI: 10.7619/jcmp.201911028.
[31]	KleinHJ, BuehlerPK, NiggemannP, et al. Expression of pancreatic stone protein is unaffected by trauma and subsequent surgery in burn patients[J]. World J Surg, 2020, 44(9): 3000-3009. DOI: 10.1007/s00268-020-05589-w.
[32]	KleinHJ, RittirschD, BuehlerPK, et al. Response of routine inflammatory biomarkers and novel Pancreatic Stone Protein to inhalation injury and its interference with sepsis detection in severely burned patients[J].Burns,2021,47(2):338-348.DOI: 10.1016/j.burns.2020.04.039.
[33]	PrazakJ,IrincheevaI,LlewelynMJ,et al.Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis[J].Crit Care,2021,25(1):182.DOI: 10.1186/s13054-021-03609-2.
[34]	QueYA, GuessousI, Dupuis-LozeronE, et al. Prognostication of mortality in critically ill patients with severe infections[J]. Chest, 2015, 148(3): 674-682. DOI: 10.1378/chest.15-0123.
[35]	杨玉丹,于玉兰,王维展.急性百草枯中毒患者血清肌腱蛋白C、胰石蛋白、动脉血乳酸水平与中毒严重指数的关系[J].中国工业医学杂志,2021,34(4):306-309.DOI: 10.13631/j.cnki.zggyyx.2021.04.005.
[36]	SamuelL. Point-of-care testing in microbiology[J]. Clin Lab Med, 2020, 40(4): 483-494. DOI: 10.1016/j.cll.2020.08.006.
[37]	ChenH,LiuKK,LiZ,et al. Point of care testing for infectious diseases[J].Clin Chim Acta,2019,493:138-147.DOI: 10.1016/j.cca.2019.03.008.