Research advances of skin tissue engineering scaffolds loaded with adipose-derived stem cells in wound repair
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摘要: 组织工程皮肤被广泛应用于重度烧伤创面、糖尿病创面等难愈性创面的治疗。种子细胞和支架材料是构建组织工程皮肤的关键元素。脂肪干细胞凭借其低免疫原性和多向分化潜能的优势逐渐成为组织工程皮肤中种子细胞的重要选择。支架材料是皮肤组织工程的重要组成部分，单一材料的改性和复合材料的制备正成为构建皮肤组织工程支架的主要研究方向。该文介绍了近年来各类负载脂肪干细胞的皮肤组织工程支架在创面修复中的应用情况，总结了应用各类支架材料构建皮肤组织工程支架时的优势与不足，期待为开发负载脂肪干细胞的组织工程皮肤提供新的思路。Abstract: Tissue engineered skin is widely used in the treatment of refractory wounds such as severe burn wounds and diabetic wounds. Seed cells and scaffold materials are the key elements for constructing tissue engineered skin. Adipose-derived stem cells have gradually become an important choice of seed cells in tissue engineered skin due to their advantages of low immunogenicity and multi-directional differentiation potential. Scaffold material is a vital part of skin tissue engineering. The modification of single material and preparation of composite materials are becoming the main research directions of the construction of skin tissue engineering scaffolds. This paper introduced the application of various kinds of skin tissue engineering scaffolds loaded with adipose-derived stem cells in wound repair in recent years, and summarized the advantages and disadvantages in using various scaffold materials to the construction of skin tissue engineering scaffolds, in order to provide new ideas for the development of tissue engineered skin loaded with adipose-derived stem cells.
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Key words:
- Tissue engineering /
- Skin /
- Adipose-derived stem cells /
- Scaffold material /
- Wound repair
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参考文献
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表1 13项关于负载ADSC的皮肤替代物用于治疗难愈性创面的临床试验
创面类型 发布年份 皮肤替代物 ADSC来源 项目编号 深Ⅱ度烧伤创面 2015 异体脂肪来源的干细胞水凝胶 同种异体 NCT02619851 糖尿病足溃疡创面 2015 异体脂肪来源的干细胞水凝胶 同种异体 NCT02394886 压疮 2015 负载脂肪来源的基质细胞的纤维蛋白密封剂 自体 NCT02375802 糖尿病足溃疡创面 2015 异体脂肪来源的干细胞水凝胶 同种异体 NCT02619877 烧伤创面 2017 异体脂肪来源的干细胞水凝胶 同种异体 NCT03183648 Ⅱ度及Ⅲ度烧伤创面 2017 负载ADSC的贫血小板血浆纤维蛋白水凝胶 同种异体 NCT03113747 烧伤创面 2017 异体脂肪来源的干细胞水凝胶 同种异体 NCT03183622 烧伤创面 2017 异体脂肪来源的干细胞水凝胶 同种异体 NCT03183648 糖尿病足溃疡创面 2017 异体脂肪来源的干细胞水凝胶 同种异体 NCT03183804 糖尿病足溃疡创面 2018 异体脂肪来源的干细胞水凝胶 同种异体 NCT03754465 糖尿病足溃疡创面 2019 负载ADSC的纤维蛋白水凝胶 同种异体 NCT03865394 糖尿病足溃疡创面 2020 异体脂肪来源的干细胞水凝胶 同种异体 NCT04569409 糖尿病足溃疡创面 2020 异体脂肪来源的干细胞水凝胶 同种异体 NCT04590703 注：ADSC为脂肪干细胞 
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