负载脂肪干细胞的皮肤组织工程支架在创面修复中的研究进展

李伟; 孔维诗; 包郁露; 孙瑜

doi:10.3760/cma.j.cn501225-20221123-00502

负载脂肪干细胞的皮肤组织工程支架在创面修复中的研究进展

doi: 10.3760/cma.j.cn501225-20221123-00502

海军军医大学第一附属医院烧伤外科，全军烧伤研究所，中国医学科学院烧伤暨烧创复合伤救治关键技术创新单元，上海　　200433

基金项目:

国家重点研发计划 2019YFA0110600, 2019YFA0110602, 2019YFA0110603

详细信息

通讯作者:
孙瑜，Email：littlefish0916@126.com

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出版历程
- 收稿日期: 2022-11-23
- 网络出版日期: 2023-11-21

Research advances of skin tissue engineering scaffolds loaded with adipose-derived stem cells in wound repair

Burn Institute of PLA, Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Shanghai 200433, China

Funds:

National Key Research and Development Program of China 2019YFA0110600, 2019YFA0110602, 2019YFA0110603

More Information

Corresponding author: Sun Yu, Email: littlefish0916@126.com

摘要

摘要: 组织工程皮肤被广泛应用于重度烧伤创面、糖尿病创面等难愈性创面的治疗。种子细胞和支架材料是构建组织工程皮肤的关键元素。脂肪干细胞凭借其低免疫原性和多向分化潜能的优势逐渐成为组织工程皮肤中种子细胞的重要选择。支架材料是皮肤组织工程的重要组成部分，单一材料的改性和复合材料的制备正成为构建皮肤组织工程支架的主要研究方向。该文介绍了近年来各类负载脂肪干细胞的皮肤组织工程支架在创面修复中的应用情况，总结了应用各类支架材料构建皮肤组织工程支架时的优势与不足，期待为开发负载脂肪干细胞的组织工程皮肤提供新的思路。
- 组织工程 /
- 皮肤 /
- 脂肪干细胞 /
- 支架材料 /
- 创面修复
Abstract: Tissue engineered skin is widely used in the treatment of refractory wounds such as severe burn wounds and diabetic wounds. Seed cells and scaffold materials are the key elements for constructing tissue engineered skin. Adipose-derived stem cells have gradually become an important choice of seed cells in tissue engineered skin due to their advantages of low immunogenicity and multi-directional differentiation potential. Scaffold material is a vital part of skin tissue engineering. The modification of single material and preparation of composite materials are becoming the main research directions of the construction of skin tissue engineering scaffolds. This paper introduced the application of various kinds of skin tissue engineering scaffolds loaded with adipose-derived stem cells in wound repair in recent years, and summarized the advantages and disadvantages in using various scaffold materials to the construction of skin tissue engineering scaffolds, in order to provide new ideas for the development of tissue engineered skin loaded with adipose-derived stem cells.
- Tissue engineering /
- Skin /
- Adipose-derived stem cells /
- Scaffold material /
- Wound repair
所有作者均声明不存在利益冲突

HTML全文

表1 13项关于负载ADSC的皮肤替代物用于治疗难愈性创面的临床试验

创面类型	发布年份	皮肤替代物	ADSC来源	项目编号
深Ⅱ度烧伤创面	2015	异体脂肪来源的干细胞水凝胶	同种异体	NCT02619851
糖尿病足溃疡创面	2015	异体脂肪来源的干细胞水凝胶	同种异体	NCT02394886
压疮	2015	负载脂肪来源的基质细胞的纤维蛋白密封剂	自体	NCT02375802
糖尿病足溃疡创面	2015	异体脂肪来源的干细胞水凝胶	同种异体	NCT02619877
烧伤创面	2017	异体脂肪来源的干细胞水凝胶	同种异体	NCT03183648
Ⅱ度及Ⅲ度烧伤创面	2017	负载ADSC的贫血小板血浆纤维蛋白水凝胶	同种异体	NCT03113747
烧伤创面	2017	异体脂肪来源的干细胞水凝胶	同种异体	NCT03183622
烧伤创面	2017	异体脂肪来源的干细胞水凝胶	同种异体	NCT03183648
糖尿病足溃疡创面	2017	异体脂肪来源的干细胞水凝胶	同种异体	NCT03183804
糖尿病足溃疡创面	2018	异体脂肪来源的干细胞水凝胶	同种异体	NCT03754465
糖尿病足溃疡创面	2019	负载ADSC的纤维蛋白水凝胶	同种异体	NCT03865394
糖尿病足溃疡创面	2020	异体脂肪来源的干细胞水凝胶	同种异体	NCT04569409
糖尿病足溃疡创面	2020	异体脂肪来源的干细胞水凝胶	同种异体	NCT04590703
注：ADSC为脂肪干细胞

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