巨噬细胞在创面愈合中的调节作用及其相关机制

贺伟峰; 闫凌峰

doi:10.3760/cma.j.cn501225-20230110-00010

巨噬细胞在创面愈合中的调节作用及其相关机制

doi: 10.3760/cma.j.cn501225-20230110-00010

贺伟峰^,,
闫凌峰

陆军军医大学（第三军医大学）第一附属医院全军烧伤研究所，创伤、烧伤与复合伤国家重点实验室，重庆市疾病蛋白质组学重点实验室，重庆　　400038

基金项目:

国家自然科学基金面上项目 31872742, 82172232

军队医学科技青年培育计划 20QNPY024

陆军军医大学科技创新能力提升专项 2019XQY12

详细信息

通讯作者:
贺伟峰，Email：heweifeng7412@aliyun.com

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出版历程
- 收稿日期: 2023-01-10

The regulatory role and related mechanisms of macrophages in wound healing

He Weifeng^,,
Yan Lingfeng

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China

Funds:

General Program of National Natural Science Foundation of China 31872742, 82172232

Military Medical Science and Technology Youth Training Program 20QNPY024

Special Project for Enhancing Science and Technology Innovation Ability of Army Medical University 2019XQY12

More Information

Corresponding author: He Weifeng, Email: heweifeng7412@aliyun.com

摘要

摘要: 创面愈合是一个被精准调控的复杂过程，包含了炎症、抗炎、再生等多个阶段。由于巨噬细胞具有明显的可塑性，可以在具有差异化的创面愈合过程中发挥重要的调节作用。巨噬细胞若未能适时表达特定功能，将会影响组织的愈合功能并导致组织病理性愈合。因此，了解巨噬细胞在创面愈合的不同阶段发挥的不同功能并进行针对性调控，对促进创伤组织的愈合再生有重要意义。该文根据创面愈合的基本过程，阐述了创面内不同类型巨噬细胞发挥的不同功能及其基本机制，并强调了未来可能应用于临床治疗的巨噬细胞调控策略。
- 伤口愈合 /
- E2F1转录因子 /
- M1型巨噬细胞 /
- M2型巨噬细胞
Abstract: Wound healing is a complex process under precise regulation, including multiple stages such as inflammation, anti-inflammatory, and regeneration. Macrophages play an important regulatory role in the differentiated process of wound healing due to their obvious plasticity. If macrophages fail to express specific functions in a timely manner, it will affect the healing function of tissues and lead to pathological tissue healing. Therefore, it is of great significance to understand the different functions of different types of macrophages and to regulate them specifically in different stages of wound healing to promote the healing and regeneration of wound tissue. In this paper, we illustrate the different functions of macrophages in the wound and their basic mechanisms, according to the basic process of wound healing, and emphasize the strategies of macrophage regulation that may be applied to clinical treatment in the future.
- Wound healing /
- E2F1 transcription factor /
- M1 macrophage /
- M2 macrophage
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