基于三维生物打印技术的皮肤组织工程研究进展

李洋; 惠涛涛; 郑东梅; 葛俊; 罗晓娥; 王琳

doi:10.3760/cma.j.cn501225-20230131-00029

基于三维生物打印技术的皮肤组织工程研究进展

doi: 10.3760/cma.j.cn501225-20230131-00029

西安外事学院医学院，精准抗衰健康产品研发与转化陕西省高校工程研究中心，西安　　710077

基金项目:

国家自然科学基金青年科学基金项目 31900939

陕西省重点研发计划 2023-YBSF-039

详细信息

通讯作者:
王琳，Email：wanglin0527@126.com

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出版历程
- 收稿日期: 2023-01-31
- 网络出版日期: 2023-11-21

Recent advances of skin tissue engineering based on three-dimensional bioprinting technology

Engineering Research Center of Personalized Anti-aging Health Product Development and Transformation of Universities of Shaanxi Province, College of Medicine, Xi'an International University, Xi'an 710077, China

Funds:

Youth Science Foundation Project of National Natural Science Foundation of China 31900939

Key Research and Development Plan of Shaanxi Province of China 2023-YBSF-039

More Information

Corresponding author: Wang Lin, Email: wanglin0527@126.com

摘要

摘要: 组织工程皮肤开发的主要目的是恢复皮肤受损严重患者的皮肤屏障功能，目前该类产品已成为临床上皮肤移植的理想替代物。随着三维生物打印技术的不断发展，构建的包含皮肤附属物等复杂结构的三维皮肤模型也日趋成熟。稳定的三维皮肤模型在皮肤生理病理研究、化妆品安全性及有效性评估，以及替代动物实验等方面具有广泛应用。该文针对三维生物打印技术进行了分类介绍，总结了常用于皮肤模型构建的生物墨水种类，综述了近年来三维生物打印技术在皮肤组织工程领域的应用研究进展，并对其未来研究发展方向和应用领域进行了探讨和展望。
- 皮肤移植 /
- 组织工程 /
- 三维生物打印 /
- 皮肤模型
Abstract: The fundamental purpose of tissue-engineered skin development is to restore the skin barrier function of patients with severe skin injury, and this kind of product has become an ideal substitute for skin transplantation in clinic at present. With the development of three-dimensional bioprinting technology, the three-dimensional skin models constructed with complex structures such as skin appendages are also becoming increasingly mature. The stable three-dimensional skin model is widely used in skin physiological and pathological research, cosmetic safety and efficacy evaluation, and alternating animal experiments. In this paper, we introduced the three-dimensional bioprinting technology in categories, summarized the types of bio-inks commonly used for skin model construction, reviewed the recent advances of three-dimensional bioprinting technology applied in the field of skin tissue engineering, and explored and prospected the future directions of its research development and application fields.
- Skin transplantation /
- Tissue engineering /
- Three-dimensional bioprinting /
- Skin model
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参考文献(31)

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