施万细胞在糖尿病周围神经病变中的作用研究进展

郝彤; 曹涛; 计鹏; 张伟锋; 陶克

doi:10.3760/cma.j.cn501225-20230727-00019

施万细胞在糖尿病周围神经病变中的作用研究进展

doi: 10.3760/cma.j.cn501225-20230727-00019

郝彤¹,
曹涛²,
计鹏¹,
张伟锋³,
陶克^4, ,

1.
空军军医大学第一附属医院全军烧伤中心，烧伤与皮肤外科，西安　　710032
2.
解放军63600部队医院外二科，酒泉　　735000
3.
陕西师范大学生命科学学院生物化学系，西安　　710062
4.
温州医科大学附属第一医院创面修复与再生医学中心创面修复科，温州　　325015

基金项目:

国家自然科学基金面上项目 82272269

详细信息

通讯作者:
陶克，Email：tao-ke2001@163.com

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出版历程
- 收稿日期: 2023-07-27
- 网络出版日期: 2023-12-19

Research advances on the role of Schwann cells in diabetic peripheral neuropathy

Hao Tong¹,
Cao Tao²,
Ji Peng¹,
Zhang Weifeng³,
Tao Ke^{4
, ,}

1.
Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China
2.
The Second Department of Surgery, 63600 PLA Hospital, Jiuquan 735000, China
3.
Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China
4.
Department of Wound Repair, Center for Wound Repair and Regenerative Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China

Funds:

General Program of National Natural Science Foundation of China 82272269

More Information

Corresponding author: Tao Ke, Email: tao-ke2001@163.com

摘要

摘要: 糖尿病周围神经病变（DPN）是糖尿病常见的慢性并发症之一，常导致脊神经、颅神经以及植物神经病变，其中以糖尿病远端对称性多发性神经病变最具代表性，包括双侧肢体疼痛、麻木和感觉异常等症状，是引起糖尿病足溃疡（DFU）的主要原因之一。施万细胞是外周神经系统中主要的神经胶质细胞，在神经损伤后的修复中起着至关重要的作用。施万细胞作为慢性高糖损伤的靶点细胞，其功能包括形成髓鞘、分泌神经营养因子、对轴突进行能量供应和引导轴突再生等在高糖作用下遭到破坏，从而抑制受损神经的修复，加速DPN的进展。因此，如能有效减轻高糖对施万细胞的损伤，将会为DPN和DFU的治疗及降低DFU的发病率提供新的途径。该文重点就施万细胞的功能及其与DPN的关系进行综述。
- 糖尿病足 /
- 髓鞘 /
- 糖尿病周围神经病变 /
- 施万细胞 /
- 神经营养因子 /
- 能量供应 /
- 轴突再生
Abstract: Diabetic peripheral neuropathy (DPN) is one of the common chronic complications of diabetes, resulting in neuropathy of spinal nerve, cranial nerve, and vegetative nerve. Diabetic distal symmetric multiple neuropathy is the most representative lesion of DPN, including symptoms of bilateral limbs pain, numbness, and paresthesia, etc. DPN is one of the main reasons causing diabetic foot ulcer (DFU). Schwann cells (SCs) are the primary glia cells of the peripheral nervous system, which play very important role in repairing after nerve injury. As the target cells of chronic hyperglycemia, SCs' functions, including the formation of myelin sheath, the secretion of neurotrophic factors, energy supplying for the axon, and the guidance of axon regeneration, etc., are damaged under the action of high glucose. The destroyed functions of SCs can inhibit the repair of damaged nerves and accelerate the progress of DPN. Therefore, if the damage of high glucose to SCs can be effectively reduced, it will provide a new way for the treatment of DPN and DFU and reduce the morbidity of DFU. This review focuses on the function of SCs and its relationship with DPN.
- Diabetic foot /
- Myelin sheath /
- Diabetic peripheral neuropathy /
- Schwann cells /
- Neurotrophic factors /
- Energy supply /
- Axonal regeneration
所有作者均声明不存在利益冲突

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