增生性瘢痕动物模型的研究进展

刘佳琦; 韩宜格; 李学拥; 马显杰

doi:10.3760/cma.j.cn501225-20231127-00208

增生性瘢痕动物模型的研究进展

doi: 10.3760/cma.j.cn501225-20231127-00208

1.
空军军医大学第二附属医院烧伤整形科,西安　　710038
2.
空军军医大学第一附属医院整形外科,西安　　710032

详细信息

通讯作者:
李学拥,Email：yuyong@fmmu.edu.cn

马显杰,Email：majing@fmmu.edu.cn

计量
- 文章访问数: 47
- HTML全文浏览量: 5
- PDF下载量: 8
- 被引次数: 0
出版历程
- 收稿日期: 2023-11-27
- 网络出版日期: 2024-11-19

Research advances on animal models of hypertrophic scar

Liu Jiaqi¹,
Han Yige¹,
Li Xueyong^{1
, ,},
Ma Xianjie^{2
, ,}

1.
Department of Plastic and Burn Surgery, the Second Affiliated Hospital, Air Force Medical University, Xi'an710038, China
2.
Department of Plastic Surgery, the First Affiliated Hospital of Air Force Medical University, Xi'an710032, China

More Information

Corresponding author: Li Xueyong, Email: yuyong@fmmu.edu.cn; Ma Xianjie, Email: majing@fmmu.edu.cn

摘要

摘要: 理想的增生性瘢痕动物模型对研究增生性瘢痕发病机制和开发更有效的治疗方法至关重要。研究者们已尝试在多种动物身上建立增生性瘢痕模型,兔耳增生性瘢痕模型是其中应用最广的一种。而近年新提出的大鼠鼠尾增生性瘢痕模型和乙醇诱导的兔耳增生性瘢痕模型等在继承传统模型优点的基础上又简化了模型制造方法,具有较大研究潜力。该文简要综述裸鼠、小鼠、大鼠、兔、猪、豚鼠及犬等增生性瘢痕动物模型的研究进展,为研究者选择合适的模型、改进现有的动物模型及开发新的动物模型提供思路。
- 瘢痕 /
- 模型,动物 /
- 小鼠,裸 /
- 小鼠 /
- 大鼠 /
- 兔 /
- 猪
Abstract: A suitable animal model of hypertrophic scar is of great importance for studying pathogenesis of hypertrophic scar and exploring more efficacious treatment. Researchers have tried to establish hypertrophic scar models in various animals, and the rabbit ear hypertrophic scar model is the most widely used one. In recent years, novel models such as the rat tail hypertrophic scar model and ethanol-induced rabbit ear hypertrophic scar model have been proposed. These models inherit the advantages of traditional models while simplifying the manufacturing process, presenting significant research potential. This paper provides the research advances on animal models of hypertrophic scar in nude mice, mice, rats, rabbits, pigs, guinea pigs, and dogs, offering insights for the researchers in selecting appropriate models, refining existing models, or creating new animal models.
- Cicatrix /
- Models, animal /
- Mice, nude /
- Mice /
- Rats /
- Rabbits /
- Swine
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参考文献(39)

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