代谢重塑及蛋白酰化修饰在瘢痕疙瘩中的作用研究进展

穆泽兰; 滕泳翔; 张键; 白南; 付妍婕

doi:10.3760/cma.j.cn501225-20231207-00229

代谢重塑及蛋白酰化修饰在瘢痕疙瘩中的作用研究进展

doi: 10.3760/cma.j.cn501225-20231207-00229

1.
山东第二医科大学临床医学院，潍坊　　261053
2.
临沂市人民医院医学美容科，临沂　　276002
3.
临沂市人民医院烧伤整形外科，临沂　　276002

基金项目:

山东省自然科学基金面上项目 ZR2021MH338

详细信息

通讯作者:
付妍婕，Email：zcfyjzzy@163.com

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- 文章访问数: 130
- HTML全文浏览量: 69
- PDF下载量: 14
- 被引次数: 0
出版历程
- 收稿日期: 2023-12-07
- 网络出版日期: 2024-06-21

Research advances on the roles of metabolic remodeling and protein acylation modification in keloids

1.
School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, China
2.
Department of Medical Cosmetology, Linyi People's Hospital, Linyi 276002, China
3.
Department of Burn and Plastic Surgery, Linyi People's Hospital, Linyi 276002, China

Funds:

General Program of Natural Science Foundation of Shandong Province of China ZR2021MH338

More Information

Corresponding author: Fu Yanjie, Email: zcfyjzzy@163.com

摘要

摘要: 瘢痕疙瘩是一种常见的皮肤疾病，其发生机制尚不完全清楚，但已有证据表明，多种因素如遗传、种族、年龄、性别、激素、感染、免疫、氧化应激等都可能与瘢痕疙瘩的发生相关。代谢重塑及蛋白酰化修饰作为2种重要的生物学过程，在多种皮肤相关疾病中发挥着重要作用。基于此，该文综述代谢重塑及蛋白酰化修饰在瘢痕疙瘩中的作用及这2种生物学过程的相互关系，并探讨靶向这2种生物学过程在预防和治疗瘢痕疙瘩中的应用前景。
- 瘢痕疙瘩 /
- 代谢 /
- 蛋白质类 /
- 酰化作用
Abstract: Keloid is a common skin disease, and the mechanism of its occurrence is not fully understood. There is evidence to show that multiple factors such as genetics, race, age, gender, hormones, infection, immunity, and oxidative stress, etc. may be related to the occurrence of keloids. Metabolic remodeling and protein acylation modification, as two important biological processes, play important roles in various skin related diseases. Based on this, this article reviews the roles of metabolic remodeling and protein acylation modification in keloids and the interrelationship between the two biological processes, and explores the application prospects of targeting the two biological processes in the prevention and treatment of keloids.
- Keloid /
- Metabolism /
- Proteins /
- Acylation
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