从昼夜节律调控角度看创面愈合

王达利; 祁放

doi:10.3760/cma.j.cn501225-20240122-00027

从昼夜节律调控角度看创面愈合

doi: 10.3760/cma.j.cn501225-20240122-00027

王达利^,,
祁放

遵义医科大学附属医院烧伤整形外科，遵义　　563003

基金项目:

国家自然科学基金地区科学基金项目 82160379

国家自然科学基金面上项目 82072195

省部共建协同创新中心项目 2020-39

贵州省科技计划 2020-4Y148

详细信息

通讯作者:
王达利，Email：daliwangzy@sina.com

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出版历程
- 收稿日期: 2024-01-22

Exploring wound healing from the perspective of circadian rhythm regulation

Wang Dali^,,
Qi Fang

Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

Funds:

Regional Science Foundation Project of National Natural Science Foundation of China 82160379

General Program of National Natural Science Foundation of China 82072195

Collaborative Innovation Center of Chinese Ministry of Education and Guizhou Province 2020-39

Science and Technology Project of Guizhou Province of China 2020-4Y148

More Information

Corresponding author: Wang Dali, Email: daliwangzy@sina.com

摘要

摘要: 创面愈合是一个涉及多种细胞类型，如免疫细胞、成纤维细胞、角质形成细胞、血管内皮细胞和干细胞的复杂且精细调控的生物学过程。近年来，科学研究揭示了昼夜节律在调控创面愈合过程中的重要作用。尽管目前对于昼夜节律如何精确调控创面愈合的分子机制还不完全清楚，但不断积累的证据已经揭示，一些关键信号和细胞功能在昼夜节律调控创面愈合中扮演着重要角色。深入理解这些机制不仅对于揭示创面愈合的基本生物学过程有重要意义，而且有助于开发新的治疗策略，如通过调整昼夜节律来指导用药、优化创伤治疗。该文通过探讨当前有关昼夜节律调控创面愈合的研究成果，以期为这一新兴领域提供一个全面的视角，并为未来的研究方向提供有价值的见解。
- 昼夜节律 /
- 伤口愈合 /
- 时间疗法 /
- 分子过程 /
- 细胞信号
Abstract: Wound healing is a complex and finely regulated biological process involving a variety of cell types, such as immune cells, fibroblasts, keratinocytes, endothelial cells, and stem cells. In recent years, scientific research has unveiled the significant role of circadian rhythms in the regulation of wound healing process. Although the molecular mechanisms by which circadian rhythms precisely regulate wound healing are not yet fully understood, accumulating evidence has revealed that some key signals and cellular functions play crucial roles in the circadian rhythm regulation of wound healing. A deeper understanding of these mechanisms is important not only to uncover the basic biological processes of wound healing, but also to develop new therapeutic strategies, such as regulating circadian rhythms to guide medication and optimize trauma treatment. By reviewing the current research results on circadian rhythm regulation of wound healing, this paper aims to provide a comprehensive perspective on this emerging field and provide valuable insights for future research directions.
- Circadian rhythm /
- Wound healing /
- Chronotherapy /
- Molecular processes /
- Cell signaling
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