Expert consensus on diagnosis and treatment of radiation-induced skin injury (2024 version)
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摘要: 放射性皮肤损伤是皮肤组织受到大剂量电离辐射作用后引起的损伤,是肿瘤局部放射治疗最常见的并发症,在核事故、放射事故和长期职业暴露等条件下也可发生。目前,国内外对于放射性皮肤损伤的诊断尚未统一标准,对其预防和治疗缺乏有效手段,亟待更多循证医学研究探索。结合国内外文献、国家职业卫生标准和现有临床经验,该共识编写组组织国内外相关领域专家,反复研讨制订针对当前放射性皮肤损伤诊断和治疗的专家共识,供临床使用参考。Abstract: Radiation-induced skin injury refers to damage caused to skin tissue after exposure to large doses of ionizing radiation. It is the most common complication in localized radiation therapy for tumors and can also occur under conditions such as nuclear accident, radiation accident, and long-term occupational exposure. Currently, there is no uniform standard for the diagnosis of radiation-induced skin injury both domestically and internationally, and there is a lack of effective methods for the prevention and treatment, necessitating more evidence-based medical researches to explore. Combining domestic and international literature, national occupational health standards, and existing clinical experience, the consensus writing group organized experts in related fields at home and abroad to repeatedly discuss and formulate an expert consensus for the diagnosis and treatment of radiation-induced skin injury, serving as a reference for clinical use.
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Key words:
- Radiation, ionizing /
- Skin /
- Ulcer /
- Diagnosis /
- Treatment /
- Expert consensus
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参考文献
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图 1 放射性皮肤损伤的诊断和治疗推荐意见
注：EGCG为表没食子儿茶素-3-没食子酸酯,EGF为表皮生长因子,GM-CSF为粒细胞-巨噬细胞集落刺激因子《放射性皮肤损伤的诊断和治疗专家共识（2024版）》编写组
Table 1. 牛津大学循证医学中心证据分级标准
证据级别 具体描述 Ⅰa 基于多个RCT的系统评价,且文献的同质性好 Ⅰb 单个RCT研究,且可信区间窄 Ⅰc 全或无的病例系列研究 Ⅱa 基于多个队列研究的系统评价 Ⅱb 单个队列研究或质量较差的RCT Ⅱc 结局研究或病因学研究 Ⅲa 病例对照研究的系统评价 Ⅲb 病例对照研究 Ⅳ 单个病例系列研究 Ⅴ 专家意见 注：RCT为随机对照试验 
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