放射性皮肤溃疡的治疗和预防策略

摘要: 放射性皮肤溃疡是对肿瘤进行放射治疗过程中产生的最常见不良反应,也是皮肤损伤中较为严重的一种溃疡。溃疡周围组织由于受到不同程度的辐射损伤,自我更新能力差,进而导致溃疡迁延不愈,继而出现持续的体液丢失、感染等症状,严重者可危及生命。皮肤溃疡部位由于血供受损或坏死,即使治愈后也易复发,是临床治疗的一大挑战。目前,尚缺乏治疗放射性皮肤溃疡的特效药物及精确给药指南,临床中仍以对症治疗为主。该文基于作者团队的临床实践经验及目前的相关文献,提出了针对不同时期放射性皮肤溃疡的药物治疗、高压氧辅助治疗、手术治疗及早期预防策略,以期为其临床治疗与预防提供参考依据。
- 皮肤溃疡 /
- 化学,药物 /
- 高压氧 /
- 外科手术 /
- 辐射损伤 /
- 创面修复
Abstract: Radiation-induced skin ulcer is the most common adverse effect of tumor radiotherapy, and it is also a serious type of ulcer among skin injuries. Due to the varying degrees of radiation damage, the surrounding tissue of ulcers has poor self-renewal ability, which leads to delayed healing of ulcers, then followed by continuous body fluid loss, infection, and other symptoms, which can be life-threatening in severe cases. Due to the damaged blood supply or necrosis, skin ulcers are prone to relapse even after healing, which is a major challenge in clinical treatment. At present, there is still a lack of specific drugs and precise administration guidelines for the treatment of radiation-induced skin ulcers, and symptomatic treatment is the main treatment in clinical practice. Based on the clinical practical experience of authors' team and current relevant literature, this paper proposed corresponding drug therapy, hyperbaric oxygen assisted therapy, surgery therapy, and early prevention strategies for radiation-induced skin ulcers at different stages, in order to provide reference for clinical treatment and prevention of radiation-induced skin ulcer.
- Skin ulcer /
- Chemistry, pharmaceutical /
- Hyperbaric oxygenation /
- Surgical procedures, operative /
- Radiation injuries /
- Wound repair
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