Abstract: Objective To observe and explore the effects of compound hyperoxic sodium chloride solution on the management of burn shock. Methods (1) Wistar rats were randomly divided into 6 groups, i. e. A group (normal rats as control), B and C groups(the rats of 30% TBSA full thickness burn with compound sodium chloride solution at 1 and 6 postburn hours ( PBHs) respectively) ; D and E groups (with hyperoxic sodium chloride solution at 1 and 6 PBHs respectively), and F group( without treatment). The changes in the serum contents of LPS, IL-6, DAO, D-lactate and M DA in the rats of each group were observed dynamically. (2) The burn patients admitted within 3 PBHs with 50% -69% TBSA burns were enrolled in the study and were randomly divided into the treatment (with hyperoxic sodium chloride solution) and the control (with sodium chloride solution) groups, The changes during shock stage, the postburn complications and the changes in the PtcO₂ and the serum contents of Hb, Hct were observed. Results All indices examined in B, C, D and E groups were evidently higher than those in A group in a progressive manner, especially in F group. The sequence was as follows : F group > C group > B group > E group > D group ( P < 0.05). The patients in treatment group could undergo the shock stage more steadily with decreased ammount of fluid infusion and increased PO₂ and less complications when compared with those in control group. But there was no obvious difference of the content of blood oxygen saturation between the two groups. Conclusion Application of hyperoxic sodium chloride solution during the early postburn stage could be beneficial to the management of burn shock.